WEKO3
アイテム
{"_buckets": {"deposit": "64c65e07-3b14-4192-9459-eb084e141c30"}, "_deposit": {"created_by": 1, "id": "80385", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "80385"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00080385", "sets": ["1"]}, "author_link": ["1011888", "1011893", "1011884", "1011890", "1011895", "1011896", "1011886", "1011894", "1011887", "1011881", "1011891", "1011880", "1011883", "1011892", "1011885", "1011889", "1011882"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "224", "bibliographicPageStart": "214", "bibliographicVolumeNumber": "2020", "bibliographic_titles": [{"bibliographic_title": "RSC Chemical Biology"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Interface peptides that mediate protein-protein interactions (PPI) are a class of important lead compounds for designing PPI inhibitors. However, Their potential as precursors for radiotracers has never been exploited. Here we reported that the interface peptides from programmed death-ligand 1 (PD-L1) can be used in positron emission tomography (PET) imaging of the programmed cell death 1 (PD-1) with high accuracy and sensitivity. Moreover, the performance differentiation between murine PD-L1 derived interface peptide (mPep-1) and human PD-L1 derived interface peptide (hPep-1) as PET tracers for PD-1 unveiled an unprecedented role of a non-critical residue in target binding, highlighting of the significance of PET imaging as a companion diagnostics in drug development. Collectively, this study not only provided a first-of-its-kind peptide-based PET tracer for PD-1 but also conveyed a unique paradigm for developing imaging agents for highly challenging protein targets, which could be used to identify other protein biomarkers involved in the PPI networks.", "subitem_description_type": "Abstract"}]}, "item_8_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Royal Society of Chemistry"}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1039/d0cb00070a", "subitem_relation_type_select": "DOI"}}]}, "item_8_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://pubs.rsc.org/en/content/articlelanding/2020/cb/d0cb00070a#!divAbstract", "subitem_relation_type_select": "URI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2633-0679", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kuan, Hu"}], "nameIdentifiers": [{"nameIdentifier": "1011880", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Xie, Lin"}], "nameIdentifiers": [{"nameIdentifier": "1011881", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hanyu, Masayuki"}], "nameIdentifiers": [{"nameIdentifier": "1011882", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Yiding"}], "nameIdentifiers": [{"nameIdentifier": "1011883", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ma, Xiaohui"}], "nameIdentifiers": [{"nameIdentifier": "1011884", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Li, Lingyun"}], "nameIdentifiers": [{"nameIdentifier": "1011885", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nagatsu, Kotaro"}], "nameIdentifiers": [{"nameIdentifier": "1011886", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Hisashi"}], "nameIdentifiers": [{"nameIdentifier": "1011887", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wang, Weizhi"}], "nameIdentifiers": [{"nameIdentifier": "1011888", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ming-Rong, Zhang"}], "nameIdentifiers": [{"nameIdentifier": "1011889", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kuan, Hu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1011890", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Lin, Xie", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1011891", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Masayuki, Hanyu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1011892", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Yiding", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1011893", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kotaro, Nagatsu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1011894", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hisashi, Suzuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1011895", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Ming-Rong", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1011896", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Harnessing PD-L1 interface peptide for positron emission tomography imaging of the PD-1 immune checkpoint", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Harnessing PD-L1 interface peptide for positron emission tomography imaging of the PD-1 immune checkpoint"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/80385", "pubdate": {"attribute_name": "公開日", "attribute_value": "2020-08-06"}, "publish_date": "2020-08-06", "publish_status": "0", "recid": "80385", "relation": {}, "relation_version_is_last": true, "title": ["Harnessing PD-L1 interface peptide for positron emission tomography imaging of the PD-1 immune checkpoint"], "weko_shared_id": -1}
Harnessing PD-L1 interface peptide for positron emission tomography imaging of the PD-1 immune checkpoint
https://repo.qst.go.jp/records/80385
https://repo.qst.go.jp/records/8038575d8d39e-8a0c-4f82-9399-bddf85dc62bf
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2020-08-06 | |||||
タイトル | ||||||
タイトル | Harnessing PD-L1 interface peptide for positron emission tomography imaging of the PD-1 immune checkpoint | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Kuan, Hu
× Kuan, Hu× Xie, Lin× Hanyu, Masayuki× Zhang, Yiding× Ma, Xiaohui× Li, Lingyun× Nagatsu, Kotaro× Suzuki, Hisashi× Wang, Weizhi× Ming-Rong, Zhang× Kuan, Hu× Lin, Xie× Masayuki, Hanyu× Zhang, Yiding× Kotaro, Nagatsu× Hisashi, Suzuki× Zhang, Ming-Rong |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Interface peptides that mediate protein-protein interactions (PPI) are a class of important lead compounds for designing PPI inhibitors. However, Their potential as precursors for radiotracers has never been exploited. Here we reported that the interface peptides from programmed death-ligand 1 (PD-L1) can be used in positron emission tomography (PET) imaging of the programmed cell death 1 (PD-1) with high accuracy and sensitivity. Moreover, the performance differentiation between murine PD-L1 derived interface peptide (mPep-1) and human PD-L1 derived interface peptide (hPep-1) as PET tracers for PD-1 unveiled an unprecedented role of a non-critical residue in target binding, highlighting of the significance of PET imaging as a companion diagnostics in drug development. Collectively, this study not only provided a first-of-its-kind peptide-based PET tracer for PD-1 but also conveyed a unique paradigm for developing imaging agents for highly challenging protein targets, which could be used to identify other protein biomarkers involved in the PPI networks. | |||||
書誌情報 |
RSC Chemical Biology 巻 2020, 号 1, p. 214-224, 発行日 2020-08 |
|||||
出版者 | ||||||
出版者 | Royal Society of Chemistry | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2633-0679 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1039/d0cb00070a | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://pubs.rsc.org/en/content/articlelanding/2020/cb/d0cb00070a#!divAbstract |