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A multimodal treatment of carbon ions irradiation, miRNA-34 and mTOR inhibitor specifically control high-grade chondrosarcoma cancer stem cells
https://repo.qst.go.jp/records/80308
https://repo.qst.go.jp/records/803083691825e-0670-4024-abb8-854871c36ab1
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-08-07 | |||||
| タイトル | ||||||
| タイトル | A multimodal treatment of carbon ions irradiation, miRNA-34 and mTOR inhibitor specifically control high-grade chondrosarcoma cancer stem cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Vares, Guillaume
× Vares, Guillaume× Ahire, Vidhula× Sunada, Shigeaki× Ho Kim, Eun× Sai, Sei× François, Chevalier× Paul-Henri, Romeo× Yamamoto, Tadashi× Nakajima, Tetsuo× Saintigny, Yannick× Sai, Sei× Nakajima, Tetsuo |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | (Background and purpose) High-grade chondrosarcomas are chemo-and radio-resistant cartilage-forming tumors of bone that often relapse and metastases. Thus, new therapeutic strategies are urgently needed. (Material and methods) Chondrosarcoma cells (CH-2879) were exposed to carbon-ion irradiation, combined with miR-34 mimic and/or rapamycin administration. The effects of treatment on cancer stem cells, stemness-associated phenotype, radioresistance and tumor-initiating properties were evaluated. (Results) We show that high-grade chondrosarcoma cells contain a population of radioresistant cancer stem cells that can be targeted by a combination of carbon-ion therapy, miR-34 mimic administration and/or rapamycin treatment that triggers FOXO3 and miR-34 over-expression. mTOR inhibition by rapamycin triggered FOXO3 and miR-34, leading to KLF4 repression. (Conclusion) Our results show that particle therapy combined with molecular treatments effectively controls cancer stem cells and may overcome treatment resistance of high-grade chondrosarcoma. |
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| 書誌情報 |
Radiotherapy and Oncology 巻 150, p. 253-261, 発行日 2020-08 |
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| 出版者 | ||||||
| 出版者 | Elsevier BV | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0167-8140 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.radonc.2020.07.034 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.thegreenjournal.com/article/S0167-8140(20)30679-4/fulltext | |||||
