{"created":"2023-05-15T14:59:11.353939+00:00","id":80308,"links":{},"metadata":{"_buckets":{"deposit":"a8fffbe0-576c-4a89-a502-4915c688571b"},"_deposit":{"created_by":1,"id":"80308","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"80308"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00080308","sets":["1"]},"author_link":["883278","883283","883282","883277","883285","883274","883281","883280","883284","883279","883276","883275"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-08","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"261","bibliographicPageStart":"253","bibliographicVolumeNumber":"150","bibliographic_titles":[{"bibliographic_title":"Radiotherapy and Oncology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"(Background and purpose)\nHigh-grade chondrosarcomas are chemo-and radio-resistant cartilage-forming tumors of bone that often relapse and metastases. Thus, new therapeutic strategies are urgently needed.\n(Material and methods)\nChondrosarcoma cells (CH-2879) were exposed to carbon-ion irradiation, combined with miR-34 mimic and/or rapamycin administration. The effects of treatment on cancer stem cells, stemness-associated phenotype, radioresistance and tumor-initiating properties were evaluated.\n(Results)\nWe show that high-grade chondrosarcoma cells contain a population of radioresistant cancer stem cells that can be targeted by a combination of carbon-ion therapy, miR-34 mimic administration and/or rapamycin treatment that triggers FOXO3 and miR-34 over-expression. mTOR inhibition by rapamycin triggered FOXO3 and miR-34, leading to KLF4 repression.\n(Conclusion)\nOur results show that particle therapy combined with molecular treatments effectively controls cancer stem cells and may overcome treatment resistance of high-grade chondrosarcoma.\n","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier BV"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.radonc.2020.07.034","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.thegreenjournal.com/article/S0167-8140(20)30679-4/fulltext","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0167-8140","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Vares, Guillaume"}],"nameIdentifiers":[{"nameIdentifier":"883274","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ahire, Vidhula"}],"nameIdentifiers":[{"nameIdentifier":"883275","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sunada, Shigeaki"}],"nameIdentifiers":[{"nameIdentifier":"883276","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ho Kim, Eun"}],"nameIdentifiers":[{"nameIdentifier":"883277","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sai, Sei"}],"nameIdentifiers":[{"nameIdentifier":"883278","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"François, Chevalier"}],"nameIdentifiers":[{"nameIdentifier":"883279","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Paul-Henri, Romeo"}],"nameIdentifiers":[{"nameIdentifier":"883280","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamoto, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"883281","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakajima, Tetsuo"}],"nameIdentifiers":[{"nameIdentifier":"883282","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saintigny, Yannick"}],"nameIdentifiers":[{"nameIdentifier":"883283","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sai, Sei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"883284","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakajima, Tetsuo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"883285","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A multimodal treatment of carbon ions irradiation, miRNA-34 and mTOR inhibitor specifically control high-grade chondrosarcoma cancer stem cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A multimodal treatment of carbon ions irradiation, miRNA-34 and mTOR inhibitor specifically control high-grade chondrosarcoma cancer stem cells"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-08-07"},"publish_date":"2020-08-07","publish_status":"0","recid":"80308","relation_version_is_last":true,"title":["A multimodal treatment of carbon ions irradiation, miRNA-34 and mTOR inhibitor specifically control high-grade chondrosarcoma cancer stem cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:38:04.954047+00:00"}