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Process development of [64Cu]Cu-ATSM: efficient stabilization and sterilization for therapeutic applications
https://repo.qst.go.jp/records/77346
https://repo.qst.go.jp/records/77346bdb09085-c4cc-40a0-9146-2f826e22d9f9
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-09-25 | |||||
| タイトル | ||||||
| タイトル | Process development of [64Cu]Cu-ATSM: efficient stabilization and sterilization for therapeutic applications | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Matsumoto, Hiroki
× Matsumoto, Hiroki× Igarashi, Chika× Kaneko, Emi× Hashimoto, Hiroki× Suzuki, Hisashi× Kawamura, Kazunori× Ming-Rong, Zhang× Higashi, Tatsuya× Yoshii, Yukie× Matsumoto, Hiroki× Igarashi, Chika× Hashimoto, Hiroki× Suzuki, Hisashi× Kawamura, Kazunori× Ming-Rong, Zhang× Higashi, Tatsuya× Yoshii, Yukie |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Hypoxia plays an important role in tumor prognosis. [64Cu]Cu-ATSM, a hypoxia-targeted radioactive agent, reportedly shows antitumor effect in vivo. For clinical application, [64Cu]Cu-ATSM must be manufactured at high concentrations to allow the administration of a therapeutic dose with safe intravenous bolus injection. Fifteen radical scavengers were tested to stabilize [64Cu]Cu-ATSM against radiolysis, and sodium l-ascorbate was selected. The optimal sterilization membrane filter was evaluated from polyvinylidene fluoride (PVDF), polyether sulfone, and mixed cellulose esters; PVDF showed the most efficient radiochemical yield after filtration. The proposed procedures can be used for the practical manufacturing of [64Cu]Cu-ATSM for therapeutic use. | |||||
| 書誌情報 |
Journal of Radioanalytical and Nuclear Chemistry 巻 322, 号 2, p. 467-475, 発行日 2019-09 |
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| 出版者 | ||||||
| 出版者 | Springer Netherlands | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0236-5731 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s10967-019-06738-9 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://link.springer.com/article/10.1007/s10967-019-06738-9#citeas | |||||
