WEKO3
アイテム
{"_buckets": {"deposit": "929d4882-665a-4b0b-81a6-d1bd998a5911"}, "_deposit": {"created_by": 1, "id": "77346", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "77346"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00077346", "sets": ["1"]}, "author_link": ["800965", "800962", "800968", "800969", "800973", "800970", "800967", "800974", "800976", "800963", "800975", "800964", "800972", "800977", "800971", "800966", "800961"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "475", "bibliographicPageStart": "467", "bibliographicVolumeNumber": "322", "bibliographic_titles": [{"bibliographic_title": "Journal of Radioanalytical and Nuclear Chemistry"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Hypoxia plays an important role in tumor prognosis. [64Cu]Cu-ATSM, a hypoxia-targeted radioactive agent, reportedly shows antitumor effect in vivo. For clinical application, [64Cu]Cu-ATSM must be manufactured at high concentrations to allow the administration of a therapeutic dose with safe intravenous bolus injection. Fifteen radical scavengers were tested to stabilize [64Cu]Cu-ATSM against radiolysis, and sodium l-ascorbate was selected. The optimal sterilization membrane filter was evaluated from polyvinylidene fluoride (PVDF), polyether sulfone, and mixed cellulose esters; PVDF showed the most efficient radiochemical yield after filtration. The proposed procedures can be used for the practical manufacturing of [64Cu]Cu-ATSM for therapeutic use.", "subitem_description_type": "Abstract"}]}, "item_8_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Springer Netherlands"}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1007/s10967-019-06738-9", "subitem_relation_type_select": "DOI"}}]}, "item_8_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://link.springer.com/article/10.1007/s10967-019-06738-9#citeas", "subitem_relation_type_select": "URI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0236-5731", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Matsumoto, Hiroki"}], "nameIdentifiers": [{"nameIdentifier": "800961", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Igarashi, Chika"}], "nameIdentifiers": [{"nameIdentifier": "800962", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kaneko, Emi"}], "nameIdentifiers": [{"nameIdentifier": "800963", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hashimoto, Hiroki"}], "nameIdentifiers": [{"nameIdentifier": "800964", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Hisashi"}], "nameIdentifiers": [{"nameIdentifier": "800965", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawamura, Kazunori"}], "nameIdentifiers": [{"nameIdentifier": "800966", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ming-Rong, Zhang"}], "nameIdentifiers": [{"nameIdentifier": "800967", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higashi, Tatsuya"}], "nameIdentifiers": [{"nameIdentifier": "800968", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshii, Yukie"}], "nameIdentifiers": [{"nameIdentifier": "800969", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsumoto, Hiroki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "800970", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Igarashi, Chika", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "800971", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hashimoto, Hiroki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "800972", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Hisashi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "800973", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawamura, Kazunori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "800974", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ming-Rong, Zhang", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "800975", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higashi, Tatsuya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "800976", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshii, Yukie", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "800977", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Process development of [64Cu]Cu-ATSM: efficient stabilization and sterilization for therapeutic applications", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Process development of [64Cu]Cu-ATSM: efficient stabilization and sterilization for therapeutic applications"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/77346", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-09-25"}, "publish_date": "2019-09-25", "publish_status": "0", "recid": "77346", "relation": {}, "relation_version_is_last": true, "title": ["Process development of [64Cu]Cu-ATSM: efficient stabilization and sterilization for therapeutic applications"], "weko_shared_id": -1}
Process development of [64Cu]Cu-ATSM: efficient stabilization and sterilization for therapeutic applications
https://repo.qst.go.jp/records/77346
https://repo.qst.go.jp/records/77346bdb09085-c4cc-40a0-9146-2f826e22d9f9
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2019-09-25 | |||||
タイトル | ||||||
タイトル | Process development of [64Cu]Cu-ATSM: efficient stabilization and sterilization for therapeutic applications | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Matsumoto, Hiroki
× Matsumoto, Hiroki× Igarashi, Chika× Kaneko, Emi× Hashimoto, Hiroki× Suzuki, Hisashi× Kawamura, Kazunori× Ming-Rong, Zhang× Higashi, Tatsuya× Yoshii, Yukie× Matsumoto, Hiroki× Igarashi, Chika× Hashimoto, Hiroki× Suzuki, Hisashi× Kawamura, Kazunori× Ming-Rong, Zhang× Higashi, Tatsuya× Yoshii, Yukie |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Hypoxia plays an important role in tumor prognosis. [64Cu]Cu-ATSM, a hypoxia-targeted radioactive agent, reportedly shows antitumor effect in vivo. For clinical application, [64Cu]Cu-ATSM must be manufactured at high concentrations to allow the administration of a therapeutic dose with safe intravenous bolus injection. Fifteen radical scavengers were tested to stabilize [64Cu]Cu-ATSM against radiolysis, and sodium l-ascorbate was selected. The optimal sterilization membrane filter was evaluated from polyvinylidene fluoride (PVDF), polyether sulfone, and mixed cellulose esters; PVDF showed the most efficient radiochemical yield after filtration. The proposed procedures can be used for the practical manufacturing of [64Cu]Cu-ATSM for therapeutic use. | |||||
書誌情報 |
Journal of Radioanalytical and Nuclear Chemistry 巻 322, 号 2, p. 467-475, 発行日 2019-09 |
|||||
出版者 | ||||||
出版者 | Springer Netherlands | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0236-5731 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s10967-019-06738-9 | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://link.springer.com/article/10.1007/s10967-019-06738-9#citeas |