@article{oai:repo.qst.go.jp:00077346,
 author = {Matsumoto, Hiroki and Igarashi, Chika and Kaneko, Emi and Hashimoto, Hiroki and Suzuki, Hisashi and Kawamura, Kazunori and Ming-Rong, Zhang and Higashi, Tatsuya and Yoshii, Yukie and Matsumoto, Hiroki and Igarashi, Chika and Hashimoto, Hiroki and Suzuki, Hisashi and Kawamura, Kazunori and Ming-Rong, Zhang and Higashi, Tatsuya and Yoshii, Yukie},
 issue = {2},
 journal = {Journal of Radioanalytical and Nuclear Chemistry},
 month = {Sep},
 note = {Hypoxia plays an important role in tumor prognosis. [64Cu]Cu-ATSM, a hypoxia-targeted radioactive agent, reportedly shows antitumor effect in vivo. For clinical application, [64Cu]Cu-ATSM must be manufactured at high concentrations to allow the administration of a therapeutic dose with safe intravenous bolus injection. Fifteen radical scavengers were tested to stabilize [64Cu]Cu-ATSM against radiolysis, and sodium l-ascorbate was selected. The optimal sterilization membrane filter was evaluated from polyvinylidene fluoride (PVDF), polyether sulfone, and mixed cellulose esters; PVDF showed the most efficient radiochemical yield after filtration. The proposed procedures can be used for the practical manufacturing of [64Cu]Cu-ATSM for therapeutic use.},
 pages = {467--475},
 title = {Process development of [64Cu]Cu-ATSM: efficient stabilization and sterilization for therapeutic applications},
 volume = {322},
 year = {2019}
}