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Despite ample evidence from\npost-mortem studies demonstrating exposure to both mild-repetitive and severe TBIs are linked to tau depositions, associations of\ntopology of tau lesions with late-onset psychiatric symptoms due to TBI have not been explored. To address this issue, we assessed\ntau deposits in long-term survivors of TBI by PET with 11C-PBB3, and evaluated those associations with late-life neuropsychiatric\noutcomes. PET data were acquired from 27 subjects in the chronic stage following mild-repetitive or severe TBI and 15 healthy\ncontrol subjects. Among the TBI patients, 14 were diagnosed as having late-onset symptoms based on the criteria of traumatic\nencephalopathy syndrome. For quantification of tau burden in TBI brains, we calculated 11C-PBB3 binding capacity (cm3), which\nis a summed voxel value of binding potentials (BP*\nND) multiplied by voxel volume. Main outcomes of the present study were\ndifferences in 11C-PBB3 binding capacity between groups, and the association of regional 11C-PBB3 binding capacity with neuropsychiatric\nsymptoms. To confirm 11C-PBB3 binding to tau deposits in TBI brains, we conducted in vitro PBB3 fluorescence and\nphospho-tau antibody immunofluorescence labelling of brain sections of chronic traumatic encephalopathy obtained from the\nBrain Bank. Our results showed that patients with TBI had higher 11C-PBB3 binding capacities in the neocortical grey and\nwhite matter segments than healthy control subjects. Furthermore, TBI patients with traumatic encephalopathy syndrome\nshowed higher 11C-PBB3 binding capacity in the white matter segment than those without traumatic encephalopathy syndrome,\nand regional assessments revealed that subgroup difference was also significant in the frontal white matter. 11C-PBB3 binding\ncapacity in the white matter segment correlated with the severity of psychosis. In vitro assays demonstrated PBB3-positive tau\ninclusions at the depth of neocortical sulci, confirming 11C-PBB3 binding to tau lesions. In conclusion, increased 11C-PBB3 binding\ncapacity is associated with late-onset neuropsychiatric symptoms following TBI, and a close correlation was found between\npsychosis and 11C-PBB3 binding capacity in the white matter", "subitem_description_type": "Abstract"}]}, "item_8_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Oxford University Press"}]}, "item_8_relation_13": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "31504227", "subitem_relation_type_select": "PMID"}}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1093/brain/awz238", "subitem_relation_type_select": "DOI"}}]}, "item_8_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awz238/5556830", "subitem_relation_type_select": "URI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0006-8950", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Takahata, Keisuke"}], "nameIdentifiers": [{"nameIdentifier": "996688", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kimura,, Yasuyuki"}], "nameIdentifiers": [{"nameIdentifier": "996689", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sahara, Naruhiko"}], "nameIdentifiers": [{"nameIdentifier": "996690", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Koga,, Shunsuke"}], "nameIdentifiers": [{"nameIdentifier": "996691", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimada,, Hitoshi"}], "nameIdentifiers": [{"nameIdentifier": "996692", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ichise, Masanori"}], "nameIdentifiers": [{"nameIdentifier": "996693", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saito, Fumie"}], "nameIdentifiers": [{"nameIdentifier": "996694", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Moriguchi, Sho"}], "nameIdentifiers": [{"nameIdentifier": "996695", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kitamura, Soichiro"}], "nameIdentifiers": [{"nameIdentifier": "996696", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kubota, Manabu"}], "nameIdentifiers": [{"nameIdentifier": "996697", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Umeda, Satoshi"}], "nameIdentifiers": [{"nameIdentifier": "996698", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Niwa, Fumitoshi"}], "nameIdentifiers": [{"nameIdentifier": "996699", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mizushima, Jin"}], "nameIdentifiers": [{"nameIdentifier": "996700", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Morimoto, Yoko"}], "nameIdentifiers": [{"nameIdentifier": "996701", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ming-Rong, Zhang"}], "nameIdentifiers": [{"nameIdentifier": "996702", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "W. 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PET-detectable tau pathology correlates with long-term neuropsychiatric outcomes in patients with traumatic brain injury
https://repo.qst.go.jp/records/76643
https://repo.qst.go.jp/records/766435d0bd4a8-8f2a-4d83-9e9c-0f8cbdc07463
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-09-03 | |||||
タイトル | ||||||
タイトル | PET-detectable tau pathology correlates with long-term neuropsychiatric outcomes in patients with traumatic brain injury | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Takahata, Keisuke
× Takahata, Keisuke× Kimura,, Yasuyuki× Sahara, Naruhiko× Koga,, Shunsuke× Shimada,, Hitoshi× Ichise, Masanori× Saito, Fumie× Moriguchi, Sho× Kitamura, Soichiro× Kubota, Manabu× Umeda, Satoshi× Niwa, Fumitoshi× Mizushima, Jin× Morimoto, Yoko× Ming-Rong, Zhang× W. Dickson, Dennis× Mimura, Masaru× Kato, Motoichiro× Suhara, Tetsuya× Higuchi, Makoto× Keisuke, Takahata× Yasuyuki, Kimura× Naruhiko, Sahara× Hitoshi, Shimada× Masanori, Ichise× Sho, Moriguchi× Soichiro, Kitamura× Manabu, Kubota× Satoshi, Umeda× Fumitoshi, Niwa× Zhang, Ming-Rong× Masaru, Mimura× Motoichiro, Kato× Tetsuya, Suhara× Makoto, Higuchi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Tau deposits is a core feature of neurodegenerative disorder following traumatic brain injury (TBI). Despite ample evidence from post-mortem studies demonstrating exposure to both mild-repetitive and severe TBIs are linked to tau depositions, associations of topology of tau lesions with late-onset psychiatric symptoms due to TBI have not been explored. To address this issue, we assessed tau deposits in long-term survivors of TBI by PET with 11C-PBB3, and evaluated those associations with late-life neuropsychiatric outcomes. PET data were acquired from 27 subjects in the chronic stage following mild-repetitive or severe TBI and 15 healthy control subjects. Among the TBI patients, 14 were diagnosed as having late-onset symptoms based on the criteria of traumatic encephalopathy syndrome. For quantification of tau burden in TBI brains, we calculated 11C-PBB3 binding capacity (cm3), which is a summed voxel value of binding potentials (BP* ND) multiplied by voxel volume. Main outcomes of the present study were differences in 11C-PBB3 binding capacity between groups, and the association of regional 11C-PBB3 binding capacity with neuropsychiatric symptoms. To confirm 11C-PBB3 binding to tau deposits in TBI brains, we conducted in vitro PBB3 fluorescence and phospho-tau antibody immunofluorescence labelling of brain sections of chronic traumatic encephalopathy obtained from the Brain Bank. Our results showed that patients with TBI had higher 11C-PBB3 binding capacities in the neocortical grey and white matter segments than healthy control subjects. Furthermore, TBI patients with traumatic encephalopathy syndrome showed higher 11C-PBB3 binding capacity in the white matter segment than those without traumatic encephalopathy syndrome, and regional assessments revealed that subgroup difference was also significant in the frontal white matter. 11C-PBB3 binding capacity in the white matter segment correlated with the severity of psychosis. In vitro assays demonstrated PBB3-positive tau inclusions at the depth of neocortical sulci, confirming 11C-PBB3 binding to tau lesions. In conclusion, increased 11C-PBB3 binding capacity is associated with late-onset neuropsychiatric symptoms following TBI, and a close correlation was found between psychosis and 11C-PBB3 binding capacity in the white matter |
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書誌情報 |
BRAIN 巻 142, 号 10, p. 3265-3279, 発行日 2019-09 |
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出版者 | ||||||
出版者 | Oxford University Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0006-8950 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 31504227 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1093/brain/awz238 | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awz238/5556830 |