{"created":"2023-05-15T14:56:25.793908+00:00","id":76643,"links":{},"metadata":{"_buckets":{"deposit":"81a8958d-4b12-4b1a-bd47-ce51c0060630"},"_deposit":{"created_by":1,"id":"76643","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"76643"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00076643","sets":["1"]},"author_link":["996696","996705","996719","996711","996708","996693","996692","996694","996688","996700","996706","996697","996703","996714","996699","996721","996717","996722","996720","996710","996707","996715","996712","996689","996698","996702","996716","996713","996701","996695","996709","996691","996690","996718","996704"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"3279","bibliographicPageStart":"3265","bibliographicVolumeNumber":"142","bibliographic_titles":[{"bibliographic_title":"BRAIN"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Tau deposits is a core feature of neurodegenerative disorder following traumatic brain injury (TBI). Despite ample evidence from\npost-mortem studies demonstrating exposure to both mild-repetitive and severe TBIs are linked to tau depositions, associations of\ntopology of tau lesions with late-onset psychiatric symptoms due to TBI have not been explored. To address this issue, we assessed\ntau deposits in long-term survivors of TBI by PET with 11C-PBB3, and evaluated those associations with late-life neuropsychiatric\noutcomes. PET data were acquired from 27 subjects in the chronic stage following mild-repetitive or severe TBI and 15 healthy\ncontrol subjects. Among the TBI patients, 14 were diagnosed as having late-onset symptoms based on the criteria of traumatic\nencephalopathy syndrome. For quantification of tau burden in TBI brains, we calculated 11C-PBB3 binding capacity (cm3), which\nis a summed voxel value of binding potentials (BP*\nND) multiplied by voxel volume. Main outcomes of the present study were\ndifferences in 11C-PBB3 binding capacity between groups, and the association of regional 11C-PBB3 binding capacity with neuropsychiatric\nsymptoms. To confirm 11C-PBB3 binding to tau deposits in TBI brains, we conducted in vitro PBB3 fluorescence and\nphospho-tau antibody immunofluorescence labelling of brain sections of chronic traumatic encephalopathy obtained from the\nBrain Bank. Our results showed that patients with TBI had higher 11C-PBB3 binding capacities in the neocortical grey and\nwhite matter segments than healthy control subjects. Furthermore, TBI patients with traumatic encephalopathy syndrome\nshowed higher 11C-PBB3 binding capacity in the white matter segment than those without traumatic encephalopathy syndrome,\nand regional assessments revealed that subgroup difference was also significant in the frontal white matter. 11C-PBB3 binding\ncapacity in the white matter segment correlated with the severity of psychosis. In vitro assays demonstrated PBB3-positive tau\ninclusions at the depth of neocortical sulci, confirming 11C-PBB3 binding to tau lesions. In conclusion, increased 11C-PBB3 binding\ncapacity is associated with late-onset neuropsychiatric symptoms following TBI, and a close correlation was found between\npsychosis and 11C-PBB3 binding capacity in the white matter","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Oxford University Press"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"31504227","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1093/brain/awz238","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awz238/5556830","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006-8950","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takahata, Keisuke"}],"nameIdentifiers":[{"nameIdentifier":"996688","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura,, Yasuyuki"}],"nameIdentifiers":[{"nameIdentifier":"996689","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sahara, Naruhiko"}],"nameIdentifiers":[{"nameIdentifier":"996690","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koga,, Shunsuke"}],"nameIdentifiers":[{"nameIdentifier":"996691","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada,, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"996692","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichise, Masanori"}],"nameIdentifiers":[{"nameIdentifier":"996693","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saito, Fumie"}],"nameIdentifiers":[{"nameIdentifier":"996694","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Moriguchi, Sho"}],"nameIdentifiers":[{"nameIdentifier":"996695","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kitamura, Soichiro"}],"nameIdentifiers":[{"nameIdentifier":"996696","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kubota, Manabu"}],"nameIdentifiers":[{"nameIdentifier":"996697","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Umeda, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"996698","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Niwa, Fumitoshi"}],"nameIdentifiers":[{"nameIdentifier":"996699","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mizushima, Jin"}],"nameIdentifiers":[{"nameIdentifier":"996700","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Morimoto, Yoko"}],"nameIdentifiers":[{"nameIdentifier":"996701","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ming-Rong, Zhang"}],"nameIdentifiers":[{"nameIdentifier":"996702","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"W. Dickson, Dennis"}],"nameIdentifiers":[{"nameIdentifier":"996703","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mimura, Masaru"}],"nameIdentifiers":[{"nameIdentifier":"996704","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Motoichiro"}],"nameIdentifiers":[{"nameIdentifier":"996705","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"996706","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"996707","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Keisuke, Takahata","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996708","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasuyuki, Kimura","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996709","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naruhiko, Sahara","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996710","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hitoshi, Shimada","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996711","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masanori, Ichise","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996712","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sho, Moriguchi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996713","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Soichiro, Kitamura","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996714","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Manabu, Kubota","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996715","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Satoshi, Umeda","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996716","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fumitoshi, Niwa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996717","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996718","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masaru, Mimura","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996719","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Motoichiro, Kato","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996720","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tetsuya, Suhara","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996721","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Makoto, Higuchi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996722","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"PET-detectable tau pathology correlates with long-term neuropsychiatric outcomes in patients with traumatic brain injury","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PET-detectable tau pathology correlates with long-term neuropsychiatric outcomes in patients with traumatic brain injury"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-09-03"},"publish_date":"2019-09-03","publish_status":"0","recid":"76643","relation_version_is_last":true,"title":["PET-detectable tau pathology correlates with long-term neuropsychiatric outcomes in patients with traumatic brain injury"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:56:00.005721+00:00"}