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Molecular Analysis of Carbon Ion-Induced Mutations in DNA Repair-Deficient Strains of Saccharomyces cerevisiae
https://repo.qst.go.jp/records/76138
https://repo.qst.go.jp/records/7613874c5c83c-e5cd-48f4-96df-f870ae1af7d0
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-06-28 | |||||
| タイトル | ||||||
| タイトル | Molecular Analysis of Carbon Ion-Induced Mutations in DNA Repair-Deficient Strains of Saccharomyces cerevisiae | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Matsuo, Yoichiro
× Matsuo, Yoichiro× Izumi, Yoshinobu× Sakamoto, Ayako× Hase, Yoshihiro× Sato, Katsuya× Shimizu, Kikuo× Matsuo, Yoichiro× Izumi, Yoshinobu× Sakamoto, Ayako× Hase, Yoshihiro× Sato, Katsuya× Shimizu, Kikuo |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Ion beams have several significantly interesting features, such as high biological effect and unique mutation spectrum. In this study, the effects of double strand breaks and 8-oxo-2'-deoxyguanosine (8-oxodG) caused by ion-beam irradiation were examined. We irradiated repair-gene-inactive strains rad52, ogg1, and msh2 using carbon ions beams, analyzed the lethality and characterized the mutations. The present observations suggested that nucleotide incorporation of oxidative damage gave only a limited effect on cell viability and genome fidelity. We also detected a hotspot at around +79 to +98 in URA3 in wild-type and mutant lines, suggesting the presence of a mutation-susceptible region. | |||||
| 書誌情報 |
Quantum Beam Science 巻 3, 号 3, p. 14, 発行日 2019-06 |
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| 出版者 | ||||||
| 出版者 | Multidisciplinary Digital Publishing Institute | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2412-382X | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3390/qubs3030014 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.mdpi.com/journal/qubs/special_issues/ionbeams_bio_med | |||||
