WEKO3
アイテム
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Individuals negative for amyloid β PET with [11 C]Pittsburgh compound B underwent clinical scoring, MR scans, and [11 C]pyridinyl-butadienyl-benzothiazole 3/PET.\n\nRESULTS:\nThere were significant differences in binding potential for [11 C]pyridinyl-butadienyl-benzothiazole 3 between PSP patients and healthy control subjects (P = 0.02). PSP patients exhibited greater radioligand retention than healthy control subjects in multiple brain regions, including frontoparietal white matter, parietal gray matter, globus pallidus, STN, red nucleus, and cerebellar dentate nucleus. [11 C]pyridinyl-butadienyl-benzothiazole 3 deposition in frontoparietal white matter, but not gray matter, was correlated with general severity of parkinsonian and PSP symptoms, whereas both gray matter and white matter [11 C]pyridinyl-butadienyl-benzothiazole 3 accumulations in the frontoparietal cortices were associated with nonverbal cognitive impairments. Autoradiographic and fluorescence labeling with pyridinyl-butadienyl-benzothiazole 3 was observed in gray matter and white matter of PSP motor cortex tissues.\n\nCONCLUSIONS:\nOur findings support the in vivo detectability of tau fibrils characteristic of PSP by [11 C]pyridinyl-butadienyl-benzothiazole 3/PET, and imply distinct and synergistic contributions of gray matter and white matte tau pathologies to clinical symptoms. [11 C]pyridinyl-butadienyl-benzothiazole 3/PET potentially provides a neuroimaging-based index for the evolution of PSP tau pathologies promoting the deterioration of motor and cognitive functions.", "subitem_description_type": "Abstract"}]}, "item_8_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Wiley Periodicals, Inc."}]}, "item_8_relation_13": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "30892739", "subitem_relation_type_select": "PMID"}}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1002/mds.27643", "subitem_relation_type_select": "DOI"}}]}, "item_8_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://onlinelibrary.wiley.com/doi/epdf/10.1002/mds.27643", "subitem_relation_type_select": "URI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0885-3185", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Endo, Hironobu"}], "nameIdentifiers": [{"nameIdentifier": "794403", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimada, Hitoshi"}], "nameIdentifiers": [{"nameIdentifier": "794404", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sahara, Naruhiko"}], "nameIdentifiers": [{"nameIdentifier": "794405", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ono, Maiko"}], "nameIdentifiers": [{"nameIdentifier": "794406", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Koga, Shunsuke"}], "nameIdentifiers": [{"nameIdentifier": "794407", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kitamura, Soichiro"}], "nameIdentifiers": [{"nameIdentifier": "794408", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Niwa, Fumitoshi"}], "nameIdentifiers": [{"nameIdentifier": "794409", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirano, Shigeki"}], "nameIdentifiers": [{"nameIdentifier": "794410", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kimura, Yasuyuki"}], "nameIdentifiers": [{"nameIdentifier": "794411", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ichise, Masanori"}], "nameIdentifiers": [{"nameIdentifier": "794412", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shinotoh, Hitoshi"}], "nameIdentifiers": [{"nameIdentifier": "794413", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Rong Zhang, Ming"}], "nameIdentifiers": [{"nameIdentifier": "794414", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kuwabara, Satoshi"}], "nameIdentifiers": [{"nameIdentifier": "794415", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "W. 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In Vivo Binding of a Tau Imaging Probe, [11C]PBB3, in Patients With Progressive Supranuclear Palsy
https://repo.qst.go.jp/records/75521
https://repo.qst.go.jp/records/75521acb4954e-6909-46c7-a1dc-6fa67792cb18
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-04-01 | |||||
タイトル | ||||||
タイトル | In Vivo Binding of a Tau Imaging Probe, [11C]PBB3, in Patients With Progressive Supranuclear Palsy | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Endo, Hironobu
× Endo, Hironobu× Shimada, Hitoshi× Sahara, Naruhiko× Ono, Maiko× Koga, Shunsuke× Kitamura, Soichiro× Niwa, Fumitoshi× Hirano, Shigeki× Kimura, Yasuyuki× Ichise, Masanori× Shinotoh, Hitoshi× Rong Zhang, Ming× Kuwabara, Satoshi× W. Dickson, Dennis× Toda, Tatsushi× Suhara, Tetsuya× Higuchi, Makoto× Endo, Hironobu× Shimada, Hitoshi× Sahara, Naruhiko× Ono, Maiko× Kitamura, Soichiro× Niwa, Fumitoshi× Hirano, Shigeki× Kimura, Yasuyuki× Ichise, Masanori× Shinoto, Hitoshi× Ming-Rong, Zhang× Suhara, Tetsuya× Higuchi, Makoto |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | BACKGROUND: [11 C]pyridinyl-butadienyl-benzothiazole 3 is a PET imaging agent designed for capturing pathological tau aggregates in diverse neurodegenerative disorders, and would be of clinical utility for neuropathological investigations of PSP. OBJECTIVES: To explore the usefulness of [11 C]pyridinyl-butadienyl-benzothiazole 3/PET in assessing characteristic distributions of tau pathologies and their association with clinical symptoms in the brains of living PSP patients. METHODS: We assessed 13 PSP patients and 13 age-matched healthy control subjects. Individuals negative for amyloid β PET with [11 C]Pittsburgh compound B underwent clinical scoring, MR scans, and [11 C]pyridinyl-butadienyl-benzothiazole 3/PET. RESULTS: There were significant differences in binding potential for [11 C]pyridinyl-butadienyl-benzothiazole 3 between PSP patients and healthy control subjects (P = 0.02). PSP patients exhibited greater radioligand retention than healthy control subjects in multiple brain regions, including frontoparietal white matter, parietal gray matter, globus pallidus, STN, red nucleus, and cerebellar dentate nucleus. [11 C]pyridinyl-butadienyl-benzothiazole 3 deposition in frontoparietal white matter, but not gray matter, was correlated with general severity of parkinsonian and PSP symptoms, whereas both gray matter and white matter [11 C]pyridinyl-butadienyl-benzothiazole 3 accumulations in the frontoparietal cortices were associated with nonverbal cognitive impairments. Autoradiographic and fluorescence labeling with pyridinyl-butadienyl-benzothiazole 3 was observed in gray matter and white matter of PSP motor cortex tissues. CONCLUSIONS: Our findings support the in vivo detectability of tau fibrils characteristic of PSP by [11 C]pyridinyl-butadienyl-benzothiazole 3/PET, and imply distinct and synergistic contributions of gray matter and white matte tau pathologies to clinical symptoms. [11 C]pyridinyl-butadienyl-benzothiazole 3/PET potentially provides a neuroimaging-based index for the evolution of PSP tau pathologies promoting the deterioration of motor and cognitive functions. |
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書誌情報 |
Movement Disorders 巻 34, 号 5, p. 744-754, 発行日 2019-03 |
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出版者 | ||||||
出版者 | Wiley Periodicals, Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0885-3185 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 30892739 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1002/mds.27643 | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://onlinelibrary.wiley.com/doi/epdf/10.1002/mds.27643 |