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Differences in bystander effect between Aldefluor positive and negative cells of fibrosarcoma using microbeam irradiation
https://repo.qst.go.jp/records/71461
https://repo.qst.go.jp/records/71461dc2b8345-50c7-4248-88c8-68e0f12ee263
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-06-02 | |||||
| タイトル | ||||||
| タイトル | Differences in bystander effect between Aldefluor positive and negative cells of fibrosarcoma using microbeam irradiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yu, Liu
× Yu, Liu× Konishi, Teruaki× Kobayashi, Alisa× Oikawa, Masakazu× Maeda, Takeshi× Uchihori, Yukio× K., Hei Tom× Wang, Yugang× 小西 輝昭× 小林 亜利紗× 及川 将一× 前田 武× 内堀 幸夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Recently, the properties of cancer stem-like cells (CSCs) have been widely investigated, especially due to resistance against radiation exposure that becomes one of major concerns in radio-cancer therapy. . However, information is rare about their performance in indirect irradiation. Here, we sorted the Aldefluor-positive cells which have a CSC property in HT1080 cell line and proved the existence of radiation-induced bystander effect in these stem-like cells and their counterpart Aldefluor-negative cells. We found that the negative ones seemed to generate a more harmful bystander effect signal and were more vulnerable to such signals in terms of the DNA double strand break (DSB)foci number measured by 53BP1. In addition, the NO scavenger c-PTIO can effectively release the bystander effect in Aldefluor-negative cells but not in positive ones. Our results first shed light on the difference between CSCs and non stem-like cancer cells (NSCCs) in radiation-induced bystander effect (RIBE), and might contribute a further understanding of the property of CSCs in radiotherapy, especially in low dose and out-of-field effect assessment. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第４回共用施設（PASTA&SPICE, NASBEE)共同研究成果報告会 | |||||
| 発表年月日 | ||||||
| 日付 | 2014-03-20 | |||||
| 日付タイプ | Issued | |||||
