{"created":"2023-05-15T14:52:20.415067+00:00","id":71461,"links":{},"metadata":{"_buckets":{"deposit":"dd115355-3396-435f-be96-cb50722adf34"},"_deposit":{"created_by":1,"id":"71461","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"71461"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00071461","sets":["10:28"]},"author_link":["702620","702628","702626","702622","702627","702616","702621","702624","702623","702625","702617","702619","702618"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-03-20","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Recently, the properties of cancer stem-like cells (CSCs) have been widely　investigated, especially due to resistance against radiation exposure that　becomes one of major concerns in radio-cancer therapy. . However, information is rare about their performance in indirect irradiation. Here, we sorted the Aldefluor-positive cells which have a CSC property in HT1080 cell line and proved the existence of radiation-induced bystander effect in these stem-like cells and their counterpart Aldefluor-negative cells. We found that the negative ones seemed to generate a more harmful bystander effect signal and were more vulnerable to such signals in terms of the DNA double strand break (DSB)foci number measured by 53BP1. In addition, the NO scavenger c-PTIO can effectively release the bystander effect in Aldefluor-negative cells but not in positive ones. Our results first shed light on the difference between CSCs and non stem-like cancer cells (NSCCs) in radiation-induced bystander effect (RIBE), and might contribute a further understanding of the property of CSCs in radiotherapy, especially in low dose and out-of-field effect assessment.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第４回共用施設（PASTA&SPICE, NASBEE)共同研究成果報告会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yu, Liu"}],"nameIdentifiers":[{"nameIdentifier":"702616","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Konishi, Teruaki"}],"nameIdentifiers":[{"nameIdentifier":"702617","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi, Alisa"}],"nameIdentifiers":[{"nameIdentifier":"702618","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oikawa, Masakazu"}],"nameIdentifiers":[{"nameIdentifier":"702619","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maeda, Takeshi"}],"nameIdentifiers":[{"nameIdentifier":"702620","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uchihori, Yukio"}],"nameIdentifiers":[{"nameIdentifier":"702621","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"K., Hei Tom"}],"nameIdentifiers":[{"nameIdentifier":"702622","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wang, Yugang"}],"nameIdentifiers":[{"nameIdentifier":"702623","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小西 輝昭","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"702624","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小林 亜利紗","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"702625","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"及川 将一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"702626","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"前田 武","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"702627","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"内堀 幸夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"702628","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Differences in bystander effect between Aldefluor positive and negative cells of fibrosarcoma using microbeam irradiation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Differences in bystander effect between Aldefluor positive and negative cells of fibrosarcoma using microbeam irradiation"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-06-02"},"publish_date":"2014-06-02","publish_status":"0","recid":"71461","relation_version_is_last":true,"title":["Differences in bystander effect between Aldefluor positive and negative cells of fibrosarcoma using microbeam irradiation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:50:59.868866+00:00"}