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同所移植膵臓癌モデルを用いた診断を目指す64Cu-RAFT-RGD PET/造影CTイメージング
https://repo.qst.go.jp/records/71337
https://repo.qst.go.jp/records/7133774b5f0df-2c16-49c4-a716-8ec028680baf
Item type | 会議発表用資料 / Presentation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2013-11-12 | |||||
タイトル | ||||||
タイトル | 同所移植膵臓癌モデルを用いた診断を目指す64Cu-RAFT-RGD PET/造影CTイメージング | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
資源タイプ | conference object | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
U, Winn Aung
× U, Winn Aung× 金, 朝暉× 古川, 高子× クラホン, ミチャエル× ボチュン, ディテェル× 曽川, 千鶴× 辻, 厚至× 藤林, 康久× デュミ, パスカル× 佐賀, 恒夫× U Winn Aung× 金 朝暉× 古川 高子× 曽川 千鶴× 辻 厚至× 藤林 康久× 佐賀 恒夫 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We did an evaluation of an integrin tracer, 64Cu-RAFT-RGD, in an orthotopic xenotransplantation model of pancreatic cancer. αvβ3 Integrin expression in pancreatic cancer cells was examined by FACS and WB. In comparative PET/CECT studies, 64Cu-RAFT-RGD uptake provided easy detection and better tumor contrast to background than 18F-FDG. Biodistribution with blocking study, autoradiography, histological, IF and IHC analyses confirmed αvβ3-specific tumor binding. Conclusion: 64Cu-RAFT-RGD PET is potentially applicable for the diagnosis of αvβ3-expressing pancreatic tumors | |||||
会議概要(会議名, 開催地, 会期, 主催者等) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 第53回日本核医学会学術総会 | |||||
発表年月日 | ||||||
日付 | 2013-11-10 | |||||
日付タイプ | Issued |