WEKO3
アイテム
CD180-negative B cells play a crucial role in the development of SLE-like morbidity in NZBWF1 mice.
https://repo.qst.go.jp/records/70718
https://repo.qst.go.jp/records/707186d4926f9-dbb7-4246-b45d-bd75581bb5ae
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-03-22 | |||||
| タイトル | ||||||
| タイトル | CD180-negative B cells play a crucial role in the development of SLE-like morbidity in NZBWF1 mice. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fujita, Kazuko
× Fujita, Kazuko× Kuwabara, Taku× Bing, Wang× Tanaka, Kaoru× Kamata, Itaru× Akasaka, Yoshikiyo× Ishii, Toshiharu× 藤田 和子× 桑原 卓× 王 冰× 田中 薫 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Systemic lupus erythematosus (SLE) is a disease usually caused by aberrant self-tolerance, in which self-reactive T and B cells are activated, resulting in production of various autoimmune antibodies. A recent study demonstrated that TLRs appear to play a role in the production of autoimmune antibodies. CD180 is a homologue of TLR 4 and a key regulator of proliferation and cell death expressing on B lymphocyte. In SLE patients, the population of CD180-negative B cells in the peripheral blood is significantly increased and changes in parallel with SLE disease activity. In the present study using NZBWF1 mice, we explored the role of CD180-negative B cells in the development of systemic autoimmune disorders and in the pathogenesis of lupus-like nephritis. The results showed that the population of CD180-negative B cells in spleen increased with age and well correlated with grades of renal lesions. In addition, CD180-negative B cells obtained from the spleen produced anti-dsDNA antibody in vitro. The amount of the antibody in peripheral blood of the mouse remarkably increased with advancing age. These results indicated that the CD180-negative B cells significantly participate in the progression of SLE-like morbid condition. In further experiments, infiltrated B cells into the renal lesion were characterized to be CD180-negative and proved to produce anti-dsDNA antibody in vitro. In conclusion, the present study revealed that CD180-negative B cells play a crucial role in the development of SLE-like morbidity in experimental NZBWF1 mice. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第40回日本免疫学会学術集会 | |||||
| 発表年月日 | ||||||
| 日付 | 2011-11-29 | |||||
| 日付タイプ | Issued | |||||
