{"created":"2023-05-15T14:51:43.972184+00:00","id":70718,"links":{},"metadata":{"_buckets":{"deposit":"87d47b94-a7b9-4afc-965b-93dbbf516c58"},"_deposit":{"created_by":1,"id":"70718","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"70718"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00070718","sets":["10:28"]},"author_link":["694652","694647","694643","694644","694645","694648","694646","694649","694650","694653","694651"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011-11-29","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Systemic lupus erythematosus (SLE) is a disease usually caused by aberrant self-tolerance, in which self-reactive T and B cells are activated, resulting in production of various autoimmune antibodies. A recent study demonstrated that TLRs appear to play a role in the production of autoimmune antibodies. CD180 is a homologue of TLR 4 and a key regulator of proliferation and cell death expressing on B lymphocyte. In SLE patients, the population of CD180-negative B cells in the peripheral blood is significantly increased and changes in parallel with SLE disease activity. In the present study using NZBWF1 mice, we explored the role of CD180-negative B cells in the development of systemic autoimmune disorders and in the pathogenesis of lupus-like nephritis. The results showed that the population of CD180-negative B cells in spleen increased with age and well correlated with grades of renal lesions. In addition, CD180-negative B cells obtained from the spleen produced anti-dsDNA antibody in vitro. The amount of the antibody in peripheral blood of the mouse remarkably increased with advancing age. These results indicated that the CD180-negative B cells significantly participate in the progression of SLE-like morbid condition. In further experiments, infiltrated B cells into the renal lesion were characterized to be CD180-negative and proved to produce anti-dsDNA antibody in vitro. In conclusion, the present study revealed that CD180-negative B cells play a crucial role in the development of SLE-like morbidity in experimental NZBWF1 mice.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第40回日本免疫学会学術集会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fujita, Kazuko"}],"nameIdentifiers":[{"nameIdentifier":"694643","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kuwabara, Taku"}],"nameIdentifiers":[{"nameIdentifier":"694644","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bing, Wang"}],"nameIdentifiers":[{"nameIdentifier":"694645","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Kaoru"}],"nameIdentifiers":[{"nameIdentifier":"694646","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamata, Itaru"}],"nameIdentifiers":[{"nameIdentifier":"694647","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akasaka, Yoshikiyo"}],"nameIdentifiers":[{"nameIdentifier":"694648","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishii, Toshiharu"}],"nameIdentifiers":[{"nameIdentifier":"694649","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤田 和子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694650","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"桑原 卓","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694651","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694652","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 薫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694653","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"CD180-negative B cells play a crucial role in the development of SLE-like morbidity in NZBWF1 mice.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"CD180-negative B cells play a crucial role in the development of SLE-like morbidity in NZBWF1 mice."}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-03-22"},"publish_date":"2012-03-22","publish_status":"0","recid":"70718","relation_version_is_last":true,"title":["CD180-negative B cells play a crucial role in the development of SLE-like morbidity in NZBWF1 mice."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:59:40.173055+00:00"}