WEKO3
アイテム
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New Bioinformatics program for the extraction of biological intelligence
https://repo.qst.go.jp/records/69870
https://repo.qst.go.jp/records/698709b280e98-22f2-4546-8ce0-e34791406a49
Item type | 会議発表用資料 / Presentation(1) | |||||
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公開日 | 2009-10-02 | |||||
タイトル | ||||||
タイトル | New Bioinformatics program for the extraction of biological intelligence | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
資源タイプ | conference object | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Taki, Keiko
× Taki, Keiko× Bing, Wang× Nakajima, Tetsuo× Oghiso, Yoichi× Magae, Junji× Nenoi, Mitsuru× et.al× 瀧 景子× 王 冰× 中島 徹夫× 根井 充 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | When we want to evaluate the radiation risks realistically, it is important to study the low-dose-rate irradiation as well as the high-dose-rate irradiation. Since the radiation effects by low-dose-rate irradiation were difficult to detect comparing to the high-dose-rate irradiation, we have not been able to understand the mechanism of the specific biological reaction of the low-dose-rate irradiation. To understand the low-dose-rate specific biological response, C57BL/6J mice were continuously irradiated with gamma-rays for 485 days at the dose rates in the range of 32 - 13,000 nGy/min whose levels were as low as about 15 times to 65,000 times over the natural background. Gene expression profiles in the kidneys from irradiated and unirradiated mice were analyzed and differentially expressed genes were identified after quality control of the data. In order to get more information of the specific pathway, we used the Boomerang program which adopted the algorithm (1) of SHAFT (2) and showed the possibility of the participation of p53 transcription factor. The results suggested that it is likely to be able to obtain more information by using the specializing method of dealing with the inclusive data even if it might be a very small response as it was not detectable. |
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会議概要(会議名, 開催地, 会期, 主催者等) | ||||||
内容記述タイプ | Other | |||||
内容記述 | CBI学会2008年大会 | |||||
発表年月日 | ||||||
日付 | 2008-10-24 | |||||
日付タイプ | Issued |