@misc{oai:repo.qst.go.jp:00069870,
 author = {Taki, Keiko and Bing, Wang and Nakajima, Tetsuo and Oghiso, Yoichi and Magae, Junji and Nenoi, Mitsuru and et.al and 瀧 景子 and 王 冰 and 中島 徹夫 and 根井 充},
 month = {Oct},
 note = {When we want to evaluate the radiation risks realistically, it is important
to study the low-dose-rate irradiation as well as the high-dose-rate
irradiation.  Since the radiation effects by low-dose-rate irradiation were
difficult to detect comparing to the high-dose-rate irradiation, we have not
been able to understand the mechanism of the specific biological reaction of
the low-dose-rate irradiation.  To understand the low-dose-rate specific
biological response, C57BL/6J mice were continuously irradiated with
gamma-rays for 485 days at the dose rates in the range of 32 - 13,000
nGy/min whose levels were as low as about 15 times to 65,000 times over the
natural background.  Gene expression profiles in the kidneys from irradiated
and unirradiated mice were analyzed and differentially expressed genes were
identified after quality control of the data.  In order to get more
information of the specific pathway, we used the Boomerang program which
adopted the algorithm (1) of SHAFT (2) and showed the possibility of the
participation of p53 transcription factor. The results suggested that it is
likely to be able to obtain more information by using the specializing
method of dealing with the inclusive data even if it might be a very small
response as it was not detectable., CBI学会2008年大会},
 title = {New Bioinformatics program for the extraction of biological intelligence},
 year = {2008}
}