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AGE DEPENDENCY OF LYMPHOMAGENESIS BY RADIATION EXPOSURE IN Mlh1-DEFICIENT MICE
https://repo.qst.go.jp/records/69843
https://repo.qst.go.jp/records/69843e887f2e3-22bf-4f97-b7d4-56684be8625a
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-09-03 | |||||
| タイトル | ||||||
| タイトル | AGE DEPENDENCY OF LYMPHOMAGENESIS BY RADIATION EXPOSURE IN Mlh1-DEFICIENT MICE | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kakinuma, Shizuko
× Kakinuma, Shizuko× Takimoto, Misaki× Kodama, Youtarou× Amasaki, Yoshiko× Nishimura, Mayumi× Shimada, Yoshiya× 柿沼 志津子× 滝本 美咲× 小玉 陽太郎× 甘崎 佳子× 西村 まゆみ× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Deficiencies in DNA mismatch repair (MMR) result in replication errors that cause frameshift mutations and/or point mutations within key tumor suppressor genes or oncogenes. Homozygous germline mutations of MMR genes, such as MLH1, MSH2 and PMS2, are manifested by an early onset of childhood T- or B-cell leukemia. MMR deficient mice, Mlh1-/- or Msh2-/-, also develop aggressive lymphomas, which are predominantly T-cell origin. We previously showed that spontaneously developed Mlh1-/- lymphomas harbored frequent frameshift mutations in Ikaros, a master transcription factor of lymphoid lineage commitment and differentiation. In this study, we examined the effect of age-at-exposure on lymphomgenesis in Mlh1-/- mice. We found that exposure of X-rays to 2 or 10 week-old mice increased the incidence of T-cell lymphomas and shortened its latency. Point mutations of Ikaros in addition to frameshift mutations were generated in radiation-induced lymphomas. In utero exposure, unexpectedly, showed no influence on T-cell lymphomagenesis. But, it accelerated B-cell lymphomagenesis. Molecular analysis is now undertaken. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | KTCC 2009 International Workshop | |||||
| 発表年月日 | ||||||
| 日付 | 2009-06-04 | |||||
| 日付タイプ | Issued | |||||
