{"created":"2023-05-15T14:51:05.529211+00:00","id":69843,"links":{},"metadata":{"_buckets":{"deposit":"cddeed99-34be-468d-ba53-dcc0fc8fb797"},"_deposit":{"created_by":1,"id":"69843","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"69843"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00069843","sets":["10:28"]},"author_link":["685718","685715","685722","685720","685717","685724","685725","685719","685723","685714","685716","685721"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-06-04","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Deficiencies in DNA mismatch repair (MMR) result in replication errors that cause frameshift mutations and/or point mutations within key tumor suppressor genes or oncogenes. Homozygous germline mutations of MMR genes, such as MLH1, MSH2 and PMS2, are manifested by an early onset of childhood T- or B-cell leukemia. MMR deficient mice, Mlh1-/- or Msh2-/-, also develop aggressive lymphomas, which are predominantly T-cell origin. We previously showed that spontaneously developed Mlh1-/- lymphomas harbored frequent frameshift mutations in Ikaros, a master transcription factor of lymphoid lineage commitment and differentiation. \nIn this study, we examined the effect of age-at-exposure on lymphomgenesis in Mlh1-/- mice. We found that exposure of X-rays to 2 or 10 week-old mice increased the incidence of T-cell lymphomas and shortened its latency. Point mutations of Ikaros in addition to frameshift mutations were generated in radiation-induced lymphomas. In utero exposure, unexpectedly, showed no influence on T-cell lymphomagenesis. But, it accelerated B-cell lymphomagenesis. Molecular analysis is now undertaken.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"KTCC 2009 International Workshop","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kakinuma, Shizuko"}],"nameIdentifiers":[{"nameIdentifier":"685714","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takimoto, Misaki"}],"nameIdentifiers":[{"nameIdentifier":"685715","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kodama, Youtarou"}],"nameIdentifiers":[{"nameIdentifier":"685716","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Amasaki, Yoshiko"}],"nameIdentifiers":[{"nameIdentifier":"685717","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishimura, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"685718","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"685719","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿沼 志津子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"685720","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"滝本 美咲","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"685721","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小玉 陽太郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"685722","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"甘崎 佳子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"685723","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 まゆみ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"685724","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 義也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"685725","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"AGE DEPENDENCY OF LYMPHOMAGENESIS BY RADIATION EXPOSURE IN Mlh1-DEFICIENT MICE","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"AGE DEPENDENCY OF LYMPHOMAGENESIS BY RADIATION EXPOSURE IN Mlh1-DEFICIENT MICE"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-09-03"},"publish_date":"2009-09-03","publish_status":"0","recid":"69843","relation_version_is_last":true,"title":["AGE DEPENDENCY OF LYMPHOMAGENESIS BY RADIATION EXPOSURE IN Mlh1-DEFICIENT MICE"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:09:47.752963+00:00"}