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Study on regional cerebral injury induced by heave-ion beams in rats
https://repo.qst.go.jp/records/67548
https://repo.qst.go.jp/records/6754804e64c41-d9d7-4c4c-8dc6-6806139804e4
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-10-17 | |||||
| タイトル | ||||||
| タイトル | Study on regional cerebral injury induced by heave-ion beams in rats | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
孫, 学智
× 孫, 学智× 高橋, 千太郎× 久保田, 善久× 佐藤, 宏× 高井, 伸彦× 張, 鋭× 野島, 久美恵× 孫 学智× 高橋 千太郎× 久保田 善久× 佐藤 宏× 高井 伸彦× 野島 久美恵 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In order to elucidate the effects of ionizing radiation on a specific brain region individually without a mutual interaction with other brain regions, we have developed an experimental system for irradiating a small and restricted region of the rat brain, using accelerated heavy-ion beams to administer a large radiation dose in the vicinity of the endpoint in the beam range. Male Sprague-Dawley rats aged 10-14 weeks were used. The left cerebral hemispheres of the rat brains were irradiated at doses of 30, 50 or 100 Gy with charged carbon particles. The spread-out Bragg peak used here successfully and satisfactorily retained its high-dose localization in the defined region. Gross anatomy of the brain was examined using a clinical MRI system at different ages of the rats after accelerated heavy-ion irradiation. Behavioral and histological changes were observed with time course and these changes were compared with MRI examination of the rats of the same age. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 日本放射線影響学会第４６回大会 | |||||
| 発表年月日 | ||||||
| 日付 | 2003-10-08 | |||||
| 日付タイプ | Issued | |||||
