@misc{oai:repo.qst.go.jp:00067548, author = {孫, 学智 and 高橋, 千太郎 and 久保田, 善久 and 佐藤, 宏 and 高井, 伸彦 and 張, 鋭 and 野島, 久美恵 and 孫 学智 and 高橋 千太郎 and 久保田 善久 and 佐藤 宏 and 高井 伸彦 and 野島 久美恵}, month = {Oct}, note = {In order to elucidate the effects of ionizing radiation on a specific brain region individually without a mutual interaction with other brain regions, we have developed an experimental system for irradiating a small and restricted region of the rat brain, using accelerated heavy-ion beams to administer a large radiation dose in the vicinity of the endpoint in the beam range. Male Sprague-Dawley rats aged 10-14 weeks were used. The left cerebral hemispheres of the rat brains were irradiated at doses of 30, 50 or 100 Gy with charged carbon particles. The spread-out Bragg peak used here successfully and satisfactorily retained its high-dose localization in the defined region. Gross anatomy of the brain was examined using a clinical MRI system at different ages of the rats after accelerated heavy-ion irradiation. Behavioral and histological changes were observed with time course and these changes were compared with MRI examination of the rats of the same age., 日本放射線影響学会第46回大会}, title = {Study on regional cerebral injury induced by heave-ion beams in rats}, year = {2003} }