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LET dependence of oxidative DNA base damage in 2-deoxyguanine aqueous solution irradiated with heavy ions
https://repo.qst.go.jp/records/62689
https://repo.qst.go.jp/records/62689fe2e5a25-fea9-4596-b10a-acb71df754a3
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-09-02 | |||||
| タイトル | ||||||
| タイトル | LET dependence of oxidative DNA base damage in 2-deoxyguanine aqueous solution irradiated with heavy ions | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hirayama, Ryoichi
× Hirayama, Ryoichi× Furusawa, Yoshiya× Murayama, Chieko× Kusano, Yohsuke× Ito, Atsushi× 平山 亮一× 古澤 佳也× 村山 千恵子× 伊藤 敦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To evaluate the contribution of indirect action mediated by OH radicals in biological effects of high LET radiations, we examined the production of 8-hydroxy-2-deoxyguanosine (8-OHdG) in 2-deoxyguanosine aqueous solution using various ion species with an LET range from 20 to 300 keV/mm. The 8-OHdG yield decreased with increasing LET. In the hypoxic irradiation condition, the yield showed constant or rather increasing tendency above about 100 keV/mm, which is consistent with an oxygen-in-the-track hypothesis to explain the diminishment of oxygen effect. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 2nd Asia-Pacific Symposium on Radiation Chemistry (APSRC-2008) | |||||
| 発表年月日 | ||||||
| 日付 | 2008-09-01 | |||||
| 日付タイプ | Issued | |||||
