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Carbon Ion Radiotherapy for Locally Recurrent Rectal Cancer
https://repo.qst.go.jp/records/62492
https://repo.qst.go.jp/records/6249268170ba2-7de4-4d6c-8aa1-0d63a0214564
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-03-26 | |||||
| タイトル | ||||||
| タイトル | Carbon Ion Radiotherapy for Locally Recurrent Rectal Cancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yamada, Shigeru
× Yamada, Shigeru× Yanagi, Takeshi× Hara, Ryusuke× Yasuda, Shigeo× Kamada, Tadashi× Katou, Hirotoshi× Tsujii, Hirohiko× Tsuji, Hiroshi× Baba, Masayuki× Mizoe, Junetsu× Miyamoto, Tadaaki× Yoshikawa, Kyosan× Kandatsu, Susumu× et.al× 山田 滋× 柳 剛× 原 竜介× 安田 茂雄× 鎌田 正× 加藤 博敏× 辻井 博彦× 辻 比呂志× 馬場 雅行× 溝江 純悦× 宮本 忠昭× 吉川 京燦× 神立 進 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: To evaluate the tolerance for and effectiveness of carbon ion radiotherapy in patients with locally recurrent rectal cancer. Patients and Methods: We conducted a phase I/II dose escalation study of carbon ion radiotherapy. Fifty-five patients with 59 sites of locally recurrent cancer received carbon ion radiotherapy. Twenty-three relapses originated in the presacral region, 16 in the pelvic side walls, 14 in the perineal region and 6 in the colorectal anastomosis. The total dose ranged from 67.2 to 73.6 gray equivalent (GyE) and was administered in 16 fixed fractions over 4 weeks (4.2 to 4.6 GyE/fraction). Results: None of 32 patients treated with the highest total dose of 73.6 GyE experienced National Cancer Institute - Common Toxicity Criteria grade 3 to 5 acute reactions. The overall local control rates were 92% at 1 year and 79% at 3 years of follow-up. Dose escalation was then halted at this level. The median survival time was 38 months (range, 7 to 52 months), and the 1- and 3-year overall survival rates were 91% and 65%, respectively. Conclusion: Carbon ion radiotherapy seems to be a safe and effective modality in the management of locally recurrent rectal cancer, providing good local control and offering a survival advantage without unacceptable morbidity. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | NIRS-MD Anderson Symposium on Clinical Issues for Particle Therapy | |||||
| 発表年月日 | ||||||
| 日付 | 2008-03-22 | |||||
| 日付タイプ | Issued | |||||
