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マウスモデルを用いた炭素イオン線治療と樹状細胞療法の併用療法の研究
https://repo.qst.go.jp/records/55879
https://repo.qst.go.jp/records/558799440d334-6bb2-449c-b0e3-ff575d2c4cf3
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-10-10 | |||||
| タイトル | ||||||
| タイトル | マウスモデルを用いた炭素イオン線治療と樹状細胞療法の併用療法の研究 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
藤田, 英俊
× 藤田, 英俊× 安藤, 謙× 下川, 卓志× 中渡, 美也子× 中村, 悦子× 藤田, 知子× 森竹, 浩之× 今井, 高志× 藤田 英俊× 安藤 謙× 下川 卓志× 中渡 美也子× 中村 悦子× 藤田 知子× 森竹 浩之× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose The goal of this study is to obtain evidence for expansion of the range of application of combination therapy of carbon-ion irradiation and dendritic cell (DC) immunotherapy. Moreover, we aim to optimize conditions for the combination therapy. Materials and methods The mouse carcinoma cell lines (LLC, LM8, NR-S1) inoculated in a leg of mice were irradiated with a single dosage of carbon-ion (2 Gy, 290 MeV/nucleon, 6 cm SOBP). At 36 hours after irradiation, DC were injected into the mice. The numbers of lung metastasis were evaluated using pathological observations. Results We established the mouse metastasis model using lung cancer cell line, LLC, and osteosarcoma cell line, LM8. Under conditions that there are no significant affect growth of transplanted tumor by the treatments, the number of lung metastasis was significantly decreased by only the combined therapy, but not by single treatment, C-ion irrradiation or DC injection. This result indicated that the combination therapy were effective to these tumors. Next we investigated the condition of DC injection from subcutaneous or tail vein in addition to the local injection. Intravenous injection of DC was available to repression of lung metastasis as well as direct injection into tumor. This finding indicated that this combination therapy is available to patients with tumor who is difficult to perform local injection of DC. |
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| 書誌情報 |
放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 巻 NIRS-M-251, 号 HIMAC-138, p. 39-40, 発行日 2012-08 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
