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ブラッグピーク近傍の重粒子イオンを用いたイオン特異的なＤＮＡ損傷の誘発と修復
https://repo.qst.go.jp/records/55436
https://repo.qst.go.jp/records/554369a0f384a-e228-4495-a222-01ab27c844a5
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-04-15 | |||||
| タイトル | ||||||
| タイトル | ブラッグピーク近傍の重粒子イオンを用いたイオン特異的なＤＮＡ損傷の誘発と修復 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
岡庭, 達也
× 岡庭, 達也× 小西, 輝昭× 中島, 宏× 竹安, 明浩× 檜枝, 光太郎× 佐藤, 幸夫× 安田, 仲宏× 古澤, 佳也× 岡庭 達也× 小西 輝昭× 中島 宏× 竹安 明弘× 檜枝 光太郎× 佐藤 幸夫× 安田 仲宏× 古澤 佳也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Action cross sections for the induction of enzyme sensitive site (ESS) by Endo? were measured around the Bragg peak of He and C ions. Ions with 6 MeV/u from the Medium-Energy Beam Course at the NIRS were extracted into air through a thin metal foil, and irradiated samples at different positions along the Bragg curve. The particle fluence was directly measured by CR39 track detector. Closed circular pBR322 plasmid DNA in 0.2 M DMSO and TE buffer was irradiated, and dsb and ssb were quantitated by electrophoretic separation and ethidium bromide staining of the DNA. Endo?converted ESS into ssb and dsb, which were denoted by ESS(ssb) and ESS(dsb). The average ratio of ESS(ssb)/ssb was 1.6, but those of ESS(dsb)/dsb was 0.5 for He ion and 0.06 for C ion. Further studies is needed to conclude whether C ion do not produce ESS(dsb) or produce base damage which can not be converted to dsb by Endo.? because of clustering of damage. | |||||
| 書誌情報 |
放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 巻 2001, p. 106-107, 発行日 2002-04 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
