@article{oai:repo.qst.go.jp:00055436,
 author = {岡庭, 達也 and 小西, 輝昭 and 中島, 宏 and 竹安, 明浩 and 檜枝, 光太郎 and 佐藤, 幸夫 and 安田, 仲宏 and 古澤, 佳也 and 岡庭 達也 and 小西 輝昭 and 中島 宏 and 竹安 明弘 and 檜枝 光太郎 and 佐藤 幸夫 and 安田 仲宏 and 古澤 佳也},
 journal = {放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書},
 month = {Apr},
 note = {Action cross sections for the induction of enzyme sensitive site (ESS) by Endo? were measured around the Bragg peak of He and C ions. Ions with 6 MeV/u from the Medium-Energy Beam Course at the NIRS were extracted into air through a thin metal foil, and irradiated samples at different positions along the Bragg curve. The particle fluence was directly measured by CR39 track detector. Closed circular pBR322 plasmid DNA in 0.2 M DMSO and TE buffer was irradiated, and dsb and ssb were quantitated by electrophoretic separation and ethidium bromide staining of the DNA. Endo?converted ESS into ssb and dsb, which were denoted by ESS(ssb) and ESS(dsb). The average ratio of ESS(ssb)/ssb was 1.6, but those of ESS(dsb)/dsb was 0.5 for He ion and 0.06 for C ion. Further studies is needed to conclude whether C ion do not produce ESS(dsb) or produce base damage which can not be converted to dsb by Endo.? because of clustering of damage.},
 pages = {106--107},
 title = {ブラッグピーク近傍の重粒子イオンを用いたイオン特異的なＤＮＡ損傷の誘発と修復},
 volume = {2001},
 year = {2002}
}