WEKO3
アイテム
{"_buckets": {"deposit": "4ec71ef1-cc4c-4381-8755-aa28d94713bd"}, "_deposit": {"created_by": 1, "id": "49192", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "49192"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00049192", "sets": ["1"]}, "author_link": ["864904", "864907", "864902", "864905", "864906", "864901", "864908", "864903"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageEnd": "590", "bibliographicPageStart": "581", "bibliographicVolumeNumber": "138", "bibliographic_titles": [{"bibliographic_title": "Acta Psychiatrica Scandinavica"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Objective: Metabolic syndrome (MS) is highly prevalent in\nschizophrenia and often a consequence of unhealthy behaviour.\nReward-related brain areas might be associated with MS, since they\nplay a major role in regulating health behaviour. This study examined\nthe relationship between MS and brain volumes related to the reward\nsystem in schizophrenia.\nMethod: We included patients with schizophrenia, with MS (MS+;\nn = 23), patients with schizophrenia, without MS (MS; n = 48), and\nhealthy controls (n = 54). Global brain volumes and volumes of\n(sub)cortical areas, part of the reward circuit, were compared between\npatients and controls. In case of a significant brain volume difference\nbetween patients and controls, the impact of MS in schizophrenia was\nexamined.\nResults: Patients had smaller total brain (TB; P = 0.001), GM\n(P = 0.010), larger ventricles (P = 0.026), and smaller reward circuit\nvolume (P \u003c 0.001) than controls. MS+ had smaller TB (P = 0.017),\nGM (P = 0.008), larger ventricles (P = 0.015), and smaller reward\ncircuit volume (P = 0.002) than MS. MS+ had smaller orbitofrontal\ncortex (OFC; P = 0.002) and insula volumes (P = 0.005) and smaller\nOFC (P = 0.008) and insula cortical surface area (P = 0.025) compared\nto MS.\nConclusion: In schizophrenia, structural brain volume reductions in\nareas of the reward circuitry appear to be related to comorbid MS.", "subitem_description_type": "Abstract"}]}, "item_8_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Wiley"}]}, "item_8_relation_13": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "30264457", "subitem_relation_type_select": "PMID"}}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1111/acps.12955", "subitem_relation_type_select": "DOI"}}]}, "item_8_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://onlinelibrary.wiley.com/doi/abs/10.1111/acps.12955", "subitem_relation_type_select": "URI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0001-690X", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "de Nijs, J."}], "nameIdentifiers": [{"nameIdentifier": "864901", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "G. Schnack, H."}], "nameIdentifiers": [{"nameIdentifier": "864902", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "G. J. C. Koevoets, M."}], "nameIdentifiers": [{"nameIdentifier": "864903", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kubota, Manabu"}], "nameIdentifiers": [{"nameIdentifier": "864904", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "S. Kahn, R."}], "nameIdentifiers": [{"nameIdentifier": "864905", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "E. M. van Haren, N."}], "nameIdentifiers": [{"nameIdentifier": "864906", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Cahn, W."}], "nameIdentifiers": [{"nameIdentifier": "864907", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kubota, Manabu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "864908", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Reward-related brain structures are smaller in patients with schizophrenia and comorbid metabolic syndrome.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Reward-related brain structures are smaller in patients with schizophrenia and comorbid metabolic syndrome."}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/49192", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-10-01"}, "publish_date": "2018-10-01", "publish_status": "0", "recid": "49192", "relation": {}, "relation_version_is_last": true, "title": ["Reward-related brain structures are smaller in patients with schizophrenia and comorbid metabolic syndrome."], "weko_shared_id": -1}
Reward-related brain structures are smaller in patients with schizophrenia and comorbid metabolic syndrome.
https://repo.qst.go.jp/records/49192
https://repo.qst.go.jp/records/491929e82a258-a8e7-4501-befd-345bcb9af884
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2018-10-01 | |||||
タイトル | ||||||
タイトル | Reward-related brain structures are smaller in patients with schizophrenia and comorbid metabolic syndrome. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
de Nijs, J.
× de Nijs, J.× G. Schnack, H.× G. J. C. Koevoets, M.× Kubota, Manabu× S. Kahn, R.× E. M. van Haren, N.× Cahn, W.× Kubota, Manabu |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objective: Metabolic syndrome (MS) is highly prevalent in schizophrenia and often a consequence of unhealthy behaviour. Reward-related brain areas might be associated with MS, since they play a major role in regulating health behaviour. This study examined the relationship between MS and brain volumes related to the reward system in schizophrenia. Method: We included patients with schizophrenia, with MS (MS+; n = 23), patients with schizophrenia, without MS (MS; n = 48), and healthy controls (n = 54). Global brain volumes and volumes of (sub)cortical areas, part of the reward circuit, were compared between patients and controls. In case of a significant brain volume difference between patients and controls, the impact of MS in schizophrenia was examined. Results: Patients had smaller total brain (TB; P = 0.001), GM (P = 0.010), larger ventricles (P = 0.026), and smaller reward circuit volume (P < 0.001) than controls. MS+ had smaller TB (P = 0.017), GM (P = 0.008), larger ventricles (P = 0.015), and smaller reward circuit volume (P = 0.002) than MS. MS+ had smaller orbitofrontal cortex (OFC; P = 0.002) and insula volumes (P = 0.005) and smaller OFC (P = 0.008) and insula cortical surface area (P = 0.025) compared to MS. Conclusion: In schizophrenia, structural brain volume reductions in areas of the reward circuitry appear to be related to comorbid MS. |
|||||
書誌情報 |
Acta Psychiatrica Scandinavica 巻 138, 号 6, p. 581-590, 発行日 2018-09 |
|||||
出版者 | ||||||
出版者 | Wiley | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0001-690X | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 30264457 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/acps.12955 | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://onlinelibrary.wiley.com/doi/abs/10.1111/acps.12955 |