WEKO3
アイテム
{"_buckets": {"deposit": "cfc25091-ad8f-4f8f-98ec-1cb45d3e1e09"}, "_deposit": {"created_by": 1, "id": "48851", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "48851"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00048851", "sets": ["1"]}, "author_link": ["492060", "492064", "492061", "492058", "492057", "492062", "492059", "492063"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-07", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "5197", "bibliographicPageStart": "5180", "bibliographicVolumeNumber": "62", "bibliographic_titles": [{"bibliographic_title": "Physics in Medicine and Biology"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The biological effect of charged-particle beams depends on both dose and particle spectrum. As one of the physical quantities describing the particle spectrum of charged-particle beams, we took the linear energy transfer (LET) throughout this study. We investigated a new therapeutic technique using two or more ion species in one treatment session, which we call an Intensity Modulated composite PArtiCle Therapy (IMPACT), for optimizing the physical dose and dose-averaged LET distributions in a patient as its proof of principle. Protons and helium, carbon, and oxygen ions were considered as ion species for IMPACT. For three cubic targets of 4 × 4 × 4, 8 × 8 × 8, and 12 × 12 × 12 cm3 defined at the center of the water phantom of 20 × 20 × 20 cm3, we made IMPACT plans of two composite fields with opposing and orthogonal geometries. The prescribed dose to the target was fixed at 1 Gy, while the prescribed LET to the target was varied from 1 keV/μm to 120 keV/μm to investigate the range of LET valid for prescription. The minimum and maximum prescribed LETs, (LT_min, LT_max), by the opposing-field geometry were (3 keV/μm, 115 keV/μm), (2 keV/μm, 84 keV/μm), and (2 keV/μm, 66 keV/μm), while those by the orthogonal-field geometry were (8 keV/μm, 98 keV/μm), (7 keV/μm, 72 keV/μm), and (8 keV/μm, 57 keV/μm) for the three targets, respectively. To show the proof of principle of IMPACT in a clinical situation, we made IMPACT plans for a prostate case. In accordance with the prescriptions, LETs in prostate, planning target volume (PTV), and rectum could be adjusted at 80 keV/μm, at 50 keV/μm, and below 30 keV/μm, respectively, while keeping the dose to the PTV at 2 Gy uniformly. IMPACT enables the optimization of the dose and the LET distributions in a patient, which will maximize the potential of charged particle therapy by expanding the therapeutic window. Further studies and developments will enable this therapeutic technique in clinical practice.", "subitem_description_type": "Abstract"}]}, "item_8_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "IOP publishing"}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1088/1361-6560/aa68d7", "subitem_relation_type_select": "DOI"}}]}, "item_8_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "https://doi.org/10.1088/1361-6560/aa68d7"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1088/1361-6560/aa68d7", "subitem_relation_type_select": "DOI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0031-9155", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Inaniwa, Taku"}], "nameIdentifiers": [{"nameIdentifier": "492057", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kanematsu, Nobuyuki"}], "nameIdentifiers": [{"nameIdentifier": "492058", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Noda, Koji"}], "nameIdentifiers": [{"nameIdentifier": "492059", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kamada, Tadashi"}], "nameIdentifiers": [{"nameIdentifier": "492060", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "稲庭 拓", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "492061", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "兼松 伸幸", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "492062", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "野田 耕司", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "492063", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "鎌田 正", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "492064", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Treatment planning of intensity modulated composite particle therapy with dose and linear energy transfer optimization", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Treatment planning of intensity modulated composite particle therapy with dose and linear energy transfer optimization"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/48851", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-05-08"}, "publish_date": "2018-05-08", "publish_status": "0", "recid": "48851", "relation": {}, "relation_version_is_last": true, "title": ["Treatment planning of intensity modulated composite particle therapy with dose and linear energy transfer optimization"], "weko_shared_id": -1}
Treatment planning of intensity modulated composite particle therapy with dose and linear energy transfer optimization
https://repo.qst.go.jp/records/48851
https://repo.qst.go.jp/records/48851b0984700-17de-4644-b7c9-37b029a525bd
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2018-05-08 | |||||
タイトル | ||||||
タイトル | Treatment planning of intensity modulated composite particle therapy with dose and linear energy transfer optimization | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Inaniwa, Taku
× Inaniwa, Taku× Kanematsu, Nobuyuki× Noda, Koji× Kamada, Tadashi× 稲庭 拓× 兼松 伸幸× 野田 耕司× 鎌田 正 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The biological effect of charged-particle beams depends on both dose and particle spectrum. As one of the physical quantities describing the particle spectrum of charged-particle beams, we took the linear energy transfer (LET) throughout this study. We investigated a new therapeutic technique using two or more ion species in one treatment session, which we call an Intensity Modulated composite PArtiCle Therapy (IMPACT), for optimizing the physical dose and dose-averaged LET distributions in a patient as its proof of principle. Protons and helium, carbon, and oxygen ions were considered as ion species for IMPACT. For three cubic targets of 4 × 4 × 4, 8 × 8 × 8, and 12 × 12 × 12 cm3 defined at the center of the water phantom of 20 × 20 × 20 cm3, we made IMPACT plans of two composite fields with opposing and orthogonal geometries. The prescribed dose to the target was fixed at 1 Gy, while the prescribed LET to the target was varied from 1 keV/μm to 120 keV/μm to investigate the range of LET valid for prescription. The minimum and maximum prescribed LETs, (LT_min, LT_max), by the opposing-field geometry were (3 keV/μm, 115 keV/μm), (2 keV/μm, 84 keV/μm), and (2 keV/μm, 66 keV/μm), while those by the orthogonal-field geometry were (8 keV/μm, 98 keV/μm), (7 keV/μm, 72 keV/μm), and (8 keV/μm, 57 keV/μm) for the three targets, respectively. To show the proof of principle of IMPACT in a clinical situation, we made IMPACT plans for a prostate case. In accordance with the prescriptions, LETs in prostate, planning target volume (PTV), and rectum could be adjusted at 80 keV/μm, at 50 keV/μm, and below 30 keV/μm, respectively, while keeping the dose to the PTV at 2 Gy uniformly. IMPACT enables the optimization of the dose and the LET distributions in a patient, which will maximize the potential of charged particle therapy by expanding the therapeutic window. Further studies and developments will enable this therapeutic technique in clinical practice. | |||||
書誌情報 |
Physics in Medicine and Biology 巻 62, p. 5180-5197, 発行日 2017-07 |
|||||
出版者 | ||||||
出版者 | IOP publishing | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0031-9155 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1088/1361-6560/aa68d7 | |||||
関連サイト | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1088/1361-6560/aa68d7 | |||||
関連名称 | https://doi.org/10.1088/1361-6560/aa68d7 |