{"created":"2023-05-15T14:37:51.602960+00:00","id":48851,"links":{},"metadata":{"_buckets":{"deposit":"cfc25091-ad8f-4f8f-98ec-1cb45d3e1e09"},"_deposit":{"created_by":1,"id":"48851","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48851"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048851","sets":["1"]},"author_link":["492060","492064","492061","492058","492057","492062","492059","492063"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-07","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5197","bibliographicPageStart":"5180","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"Physics in Medicine and Biology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The biological effect of charged-particle beams depends on both dose and particle spectrum. As one of the physical quantities describing the particle spectrum of charged-particle beams, we took the linear energy transfer (LET) throughout this study. We investigated a new therapeutic technique using two or more ion species in one treatment session, which we call an Intensity Modulated composite PArtiCle Therapy (IMPACT), for optimizing the physical dose and dose-averaged LET distributions in a patient as its proof of principle. Protons and helium, carbon, and oxygen ions were considered as ion species for IMPACT. For three cubic targets of 4 × 4 × 4, 8 × 8 × 8, and 12 × 12 × 12 cm3 defined at the center of the water phantom of 20 × 20 × 20 cm3, we made IMPACT plans of two composite fields with opposing and orthogonal geometries. The prescribed dose to the target was fixed at 1 Gy, while the prescribed LET to the target was varied from 1 keV/μm to 120 keV/μm to investigate the range of LET valid for prescription. The minimum and maximum prescribed LETs, (LT_min, LT_max), by the opposing-field geometry were (3 keV/μm, 115 keV/μm), (2 keV/μm, 84 keV/μm), and (2 keV/μm, 66 keV/μm), while those by the orthogonal-field geometry were (8 keV/μm, 98 keV/μm), (7 keV/μm, 72 keV/μm), and (8 keV/μm, 57 keV/μm) for the three targets, respectively. To show the proof of principle of IMPACT in a clinical situation, we made IMPACT plans for a prostate case. In accordance with the prescriptions, LETs in prostate, planning target volume (PTV), and rectum could be adjusted at 80 keV/μm, at 50 keV/μm, and below 30 keV/μm, respectively, while keeping the dose to the PTV at 2 Gy uniformly. IMPACT enables the optimization of the dose and the LET distributions in a patient, which will maximize the potential of charged particle therapy by expanding the therapeutic window. Further studies and developments will enable this therapeutic technique in clinical practice.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"IOP publishing"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1088/1361-6560/aa68d7","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://doi.org/10.1088/1361-6560/aa68d7"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1088/1361-6560/aa68d7","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0031-9155","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Inaniwa, Taku"}],"nameIdentifiers":[{"nameIdentifier":"492057","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kanematsu, Nobuyuki"}],"nameIdentifiers":[{"nameIdentifier":"492058","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Noda, Koji"}],"nameIdentifiers":[{"nameIdentifier":"492059","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamada, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"492060","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"稲庭 拓","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"492061","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"兼松 伸幸","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"492062","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野田 耕司","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"492063","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"492064","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Treatment planning of intensity modulated composite particle therapy with dose and linear energy transfer optimization","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Treatment planning of intensity modulated composite particle therapy with dose and linear energy transfer optimization"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-08"},"publish_date":"2018-05-08","publish_status":"0","recid":"48851","relation_version_is_last":true,"title":["Treatment planning of intensity modulated composite particle therapy with dose and linear energy transfer optimization"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:23:38.830981+00:00"}