WEKO3
アイテム
{"_buckets": {"deposit": "63cae32f-ead4-46f2-a18c-cddea1b36c13"}, "_deposit": {"created_by": 1, "id": "48590", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "48590"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00048590", "sets": ["1"]}, "author_link": ["874410", "874406", "874404", "874408", "874409", "874401", "874400", "874405", "874403", "874407", "874402", "874398", "874399"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "845", "bibliographicPageStart": "835", "bibliographicVolumeNumber": "20", "bibliographic_titles": [{"bibliographic_title": "Molecular Imaging and Biology"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "\nPurpose\n\nPrevious studies demonstrated the utility of [18F]fluoropropyl-(+)-dihydrotetrabenazine ([18F]FP-(+)-DTBZ) as a positron emission tomography (PET) radiotracer for the vesicular monoamine transporter type 2 (VMAT2) to quantify beta cell mass in healthy control (HC) and type 1 diabetes mellitus (T1DM) groups. Quantification of specific binding requires measurement of non-displaceable uptake. Our goal was to identify a reference tissue (renal cortex or spleen) to quantify pancreatic non-specific binding of [18F]FP-(+)-DTBZ with the inactive enantiomer, [18F]FP-(−)-DTBZ. This was the first human study of [18F]FP-(−)-DTBZ.\n\n\nProcedures\n\nSix HCs and four T1DM patients were scanned on separate days after injection of [18F]FP-(+)-DTBZ or [18F]FP-(−)-DTBZ. Distribution volumes (VT) and standardized uptake values (SUVs) were compared between groups. Three methods for calculation of non-displaceable uptake (VND) or reference SUV were applied: (1) use of [18F]FP-(+)-DTBZ reference VT as VND, assuming VND is uniform across organs; (2) use of [18F]FP-(−)-DTBZ pancreatic VT as VND, assuming that VND is uniform between enantiomers in the pancreas; and (3) use of a scaled [18F]FP-(+)-DTBZ reference VT as VND, assuming that a ratio of non-displaceable uptake between organs is uniform between enantiomers. Group differences in VT (or SUV), binding potential (BPND), or SUV ratio (SUVR) were estimated using these three methods.\n\n\nResults\n\n[18F]FP-(−)-DTBZ VT values were different among organs, and VT(+) and VT(−) were also different in the renal cortex and spleen. Method 3 with the spleen to estimate VND (or reference SUV) gave the highest non-displaceable uptake and the largest HC vs. T1DM group differences. Significant group differences were also observed in VT (or SUV) with method 1 using spleen. SUV was affected by differences in the input function between groups and between enantiomers.\n\n\nConclusions\n\nNon-displaceable uptake was different among organs and between enantiomers. Use of scaled spleen VT values for VND is a suitable method for quantification of VMAT2 in the pancreas.\n", "subitem_description_type": "Abstract"}]}, "item_8_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Springer International Publishing"}]}, "item_8_relation_13": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "29468404", "subitem_relation_type_select": "PMID"}}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1007/s11307-018-1170-6", "subitem_relation_type_select": "DOI"}}]}, "item_8_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://link.springer.com/article/10.1007/s11307-018-1170-6", "subitem_relation_type_select": "URI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1536-1632", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Naganawa , Mika"}], "nameIdentifiers": [{"nameIdentifier": "874398", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Lim, Keunpoong"}], "nameIdentifiers": [{"nameIdentifier": "874399", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "B. Nabulsi, Nabeel"}], "nameIdentifiers": [{"nameIdentifier": "874400", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shu-fei, Lin "}], "nameIdentifiers": [{"nameIdentifier": "874401", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Labaree, David"}], "nameIdentifiers": [{"nameIdentifier": "874402", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ropchan, Jim"}], "nameIdentifiers": [{"nameIdentifier": "874403", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "C. Herold, Kevan"}], "nameIdentifiers": [{"nameIdentifier": "874404", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Huang, Yiyun"}], "nameIdentifiers": [{"nameIdentifier": "874405", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Harris, Paul"}], "nameIdentifiers": [{"nameIdentifier": "874406", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ichise, Masanori"}], "nameIdentifiers": [{"nameIdentifier": "874407", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "W. Cline, Gary"}], "nameIdentifiers": [{"nameIdentifier": "874408", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "E. Carson, Richard"}], "nameIdentifiers": [{"nameIdentifier": "874409", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ichise, Masanori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "874410", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Evaluation of Pancreatic VMAT2 Binding with Active and Inactive Enantiomers of [18F]FP-DTBZ in Healthy Subjects and Patients with Type 1 Diabetes", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Evaluation of Pancreatic VMAT2 Binding with Active and Inactive Enantiomers of [18F]FP-DTBZ in Healthy Subjects and Patients with Type 1 Diabetes"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/48590", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-03-14"}, "publish_date": "2018-03-14", "publish_status": "0", "recid": "48590", "relation": {}, "relation_version_is_last": true, "title": ["Evaluation of Pancreatic VMAT2 Binding with Active and Inactive Enantiomers of [18F]FP-DTBZ in Healthy Subjects and Patients with Type 1 Diabetes"], "weko_shared_id": -1}
Evaluation of Pancreatic VMAT2 Binding with Active and Inactive Enantiomers of [18F]FP-DTBZ in Healthy Subjects and Patients with Type 1 Diabetes
https://repo.qst.go.jp/records/48590
https://repo.qst.go.jp/records/4859098a87470-1a5e-455d-8477-cc24952d7463
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2018-03-14 | |||||
タイトル | ||||||
タイトル | Evaluation of Pancreatic VMAT2 Binding with Active and Inactive Enantiomers of [18F]FP-DTBZ in Healthy Subjects and Patients with Type 1 Diabetes | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Naganawa , Mika
× Naganawa , Mika× Lim, Keunpoong× B. Nabulsi, Nabeel× Shu-fei, Lin× Labaree, David× Ropchan, Jim× C. Herold, Kevan× Huang, Yiyun× Harris, Paul× Ichise, Masanori× W. Cline, Gary× E. Carson, Richard× Ichise, Masanori |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Purpose Previous studies demonstrated the utility of [18F]fluoropropyl-(+)-dihydrotetrabenazine ([18F]FP-(+)-DTBZ) as a positron emission tomography (PET) radiotracer for the vesicular monoamine transporter type 2 (VMAT2) to quantify beta cell mass in healthy control (HC) and type 1 diabetes mellitus (T1DM) groups. Quantification of specific binding requires measurement of non-displaceable uptake. Our goal was to identify a reference tissue (renal cortex or spleen) to quantify pancreatic non-specific binding of [18F]FP-(+)-DTBZ with the inactive enantiomer, [18F]FP-(−)-DTBZ. This was the first human study of [18F]FP-(−)-DTBZ. Procedures Six HCs and four T1DM patients were scanned on separate days after injection of [18F]FP-(+)-DTBZ or [18F]FP-(−)-DTBZ. Distribution volumes (VT) and standardized uptake values (SUVs) were compared between groups. Three methods for calculation of non-displaceable uptake (VND) or reference SUV were applied: (1) use of [18F]FP-(+)-DTBZ reference VT as VND, assuming VND is uniform across organs; (2) use of [18F]FP-(−)-DTBZ pancreatic VT as VND, assuming that VND is uniform between enantiomers in the pancreas; and (3) use of a scaled [18F]FP-(+)-DTBZ reference VT as VND, assuming that a ratio of non-displaceable uptake between organs is uniform between enantiomers. Group differences in VT (or SUV), binding potential (BPND), or SUV ratio (SUVR) were estimated using these three methods. Results [18F]FP-(−)-DTBZ VT values were different among organs, and VT(+) and VT(−) were also different in the renal cortex and spleen. Method 3 with the spleen to estimate VND (or reference SUV) gave the highest non-displaceable uptake and the largest HC vs. T1DM group differences. Significant group differences were also observed in VT (or SUV) with method 1 using spleen. SUV was affected by differences in the input function between groups and between enantiomers. Conclusions Non-displaceable uptake was different among organs and between enantiomers. Use of scaled spleen VT values for VND is a suitable method for quantification of VMAT2 in the pancreas. |
|||||
書誌情報 |
Molecular Imaging and Biology 巻 20, 号 5, p. 835-845, 発行日 2018-10 |
|||||
出版者 | ||||||
出版者 | Springer International Publishing | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1536-1632 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 29468404 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s11307-018-1170-6 | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://link.springer.com/article/10.1007/s11307-018-1170-6 |