{"created":"2023-05-15T14:37:40.054445+00:00","id":48590,"links":{},"metadata":{"_buckets":{"deposit":"63cae32f-ead4-46f2-a18c-cddea1b36c13"},"_deposit":{"created_by":1,"id":"48590","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48590"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048590","sets":["1"]},"author_link":["874410","874406","874404","874408","874409","874401","874400","874405","874403","874407","874402","874398","874399"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"845","bibliographicPageStart":"835","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"Molecular Imaging  and Biology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"\nPurpose\n\nPrevious studies demonstrated the utility of [18F]fluoropropyl-(+)-dihydrotetrabenazine ([18F]FP-(+)-DTBZ) as a positron emission tomography (PET) radiotracer for the vesicular monoamine transporter type 2 (VMAT2) to quantify beta cell mass in healthy control (HC) and type 1 diabetes mellitus (T1DM) groups. Quantification of specific binding requires measurement of non-displaceable uptake. Our goal was to identify a reference tissue (renal cortex or spleen) to quantify pancreatic non-specific binding of [18F]FP-(+)-DTBZ with the inactive enantiomer, [18F]FP-(−)-DTBZ. This was the first human study of [18F]FP-(−)-DTBZ.\n\n\nProcedures\n\nSix HCs and four T1DM patients were scanned on separate days after injection of [18F]FP-(+)-DTBZ or [18F]FP-(−)-DTBZ. Distribution volumes (VT) and standardized uptake values (SUVs) were compared between groups. Three methods for calculation of non-displaceable uptake (VND) or reference SUV were applied: (1) use of [18F]FP-(+)-DTBZ reference VT as VND, assuming VND is uniform across organs; (2) use of [18F]FP-(−)-DTBZ pancreatic VT as VND, assuming that VND is uniform between enantiomers in the pancreas; and (3) use of a scaled [18F]FP-(+)-DTBZ reference VT as VND, assuming that a ratio of non-displaceable uptake between organs is uniform between enantiomers. Group differences in VT (or SUV), binding potential (BPND), or SUV ratio (SUVR) were estimated using these three methods.\n\n\nResults\n\n[18F]FP-(−)-DTBZ VT values were different among organs, and VT(+) and VT(−) were also different in the renal cortex and spleen. Method 3 with the spleen to estimate VND (or reference SUV) gave the highest non-displaceable uptake and the largest HC vs. T1DM group differences. Significant group differences were also observed in VT (or SUV) with method 1 using spleen. SUV was affected by differences in the input function between groups and between enantiomers.\n\n\nConclusions\n\nNon-displaceable uptake was different among organs and between enantiomers. Use of scaled spleen VT values for VND is a suitable method for quantification of VMAT2 in the pancreas.\n","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer International Publishing"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"29468404","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s11307-018-1170-6","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://link.springer.com/article/10.1007/s11307-018-1170-6","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1536-1632","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Naganawa , Mika"}],"nameIdentifiers":[{"nameIdentifier":"874398","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lim, Keunpoong"}],"nameIdentifiers":[{"nameIdentifier":"874399","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"B. Nabulsi, Nabeel"}],"nameIdentifiers":[{"nameIdentifier":"874400","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shu-fei, Lin "}],"nameIdentifiers":[{"nameIdentifier":"874401","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Labaree, David"}],"nameIdentifiers":[{"nameIdentifier":"874402","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ropchan, Jim"}],"nameIdentifiers":[{"nameIdentifier":"874403","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"C. Herold, Kevan"}],"nameIdentifiers":[{"nameIdentifier":"874404","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Huang, Yiyun"}],"nameIdentifiers":[{"nameIdentifier":"874405","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Harris, Paul"}],"nameIdentifiers":[{"nameIdentifier":"874406","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichise, Masanori"}],"nameIdentifiers":[{"nameIdentifier":"874407","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"W. Cline, Gary"}],"nameIdentifiers":[{"nameIdentifier":"874408","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"E. Carson, Richard"}],"nameIdentifiers":[{"nameIdentifier":"874409","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichise, Masanori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"874410","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Evaluation of Pancreatic VMAT2 Binding with Active and Inactive Enantiomers of [18F]FP-DTBZ in Healthy Subjects and Patients with Type 1 Diabetes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Evaluation of Pancreatic VMAT2 Binding with Active and Inactive Enantiomers of [18F]FP-DTBZ in Healthy Subjects and Patients with Type 1 Diabetes"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-03-14"},"publish_date":"2018-03-14","publish_status":"0","recid":"48590","relation_version_is_last":true,"title":["Evaluation of Pancreatic VMAT2 Binding with Active and Inactive Enantiomers of [18F]FP-DTBZ in Healthy Subjects and Patients with Type 1 Diabetes"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:48:30.975765+00:00"}