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Clinical outcomes of carbon ion radiotherapy with concurrent chemotherapy for locally advanced uterine cervical adenocarcinoma in a phase 1/2 clinical trial (Protocol 1001).
https://repo.qst.go.jp/records/48551
https://repo.qst.go.jp/records/485517184ef66-0707-49fc-aac6-2fd96f6312bb
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-03-05 | |||||
タイトル | ||||||
タイトル | Clinical outcomes of carbon ion radiotherapy with concurrent chemotherapy for locally advanced uterine cervical adenocarcinoma in a phase 1/2 clinical trial (Protocol 1001). | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Okonogi, Noriyuki
× Okonogi, Noriyuki× Wakatsuki, Masaru× Kato, Shingo× Karasawa, Kumiko× Kiyohara, Hiroki× Shiba, Shintaro× Kobayashi, Daijiro× Nakano, Takashi× Kamada, Tadashi× Syozu, Makio× 小此木 範之× 若月 優× 加藤 眞吾× 唐澤 久美子× 清原 浩樹× 柴 慎太郎× 小林 大二郎× 中野 隆史× 鎌田 正× 生水 真紀夫 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We conducted a phase 1/2 study to evaluate the efficacy and safety of carbon ion radiotherapy (C-ion RT) with concurrent chemotherapy for locally advanced uterine cervical adenocarcinoma. Thirty-three patients were enrolled between April 2010 and March 2014. Treatment consisted of C-ion RT with concurrent weekly cisplatin at a dose of 40 mg/m2 . In the phase 1 component, the total dose was escalated from 68.0 Gy (relative biological effectiveness [RBE]) to 74.4 Gy (RBE) to determine the maximum tolerated dose of C-ion RT. In the phase 2 component, the efficacy and safety of C-ion RT with concurrent chemotherapy were evaluated using the dose determined in the phase 1 component. The median follow-up duration was 30 months. Two patients did not receive chemotherapy because of anemia or leukocytopenia immediately prior to commencing treatment; 31 patients were analyzed. None of the patients developed dose-limiting toxicities. The recommended dose (RD) was determined to be 74.4 Gy (RBE). In the phase 2 component, two patients developed Grade 3-4 toxicities in the gastrointestinal tract, due to repeated laser coagulation or peritonitis caused by appendicitis. In the patients treated with the RD, the 2-year local control, progression-free survival, and overall survival rates were 71%, 56%, and 88%, respectively. C-ion RT with concurrent weekly cisplatin was well tolerated in patients with locally advanced uterine cervical adenocarcinoma. Our findings support further investigations into the efficacy of this strategy. | |||||
書誌情報 |
Cancer medicine 巻 7, 号 2, p. 351-359, 発行日 2018-02 |
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出版者 | ||||||
出版者 | John Wiley & Sons Ltd | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2045-7634 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 29341491 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1002/cam4.1305 |