{"created":"2023-05-15T14:37:37.957194+00:00","id":48551,"links":{},"metadata":{"_buckets":{"deposit":"09a589a8-7c75-43a9-9924-e5198feb030a"},"_deposit":{"created_by":1,"id":"48551","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48551"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048551","sets":["1"]},"author_link":["488146","488155","488162","488150","488159","488151","488149","488158","488145","488157","488161","488154","488163","488147","488160","488152","488156","488153","488144","488148"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"359","bibliographicPageStart":"351","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"Cancer medicine"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We conducted a phase 1/2 study to evaluate the efficacy and safety of carbon ion radiotherapy (C-ion RT) with concurrent chemotherapy for locally advanced uterine cervical adenocarcinoma. Thirty-three patients were enrolled between April 2010 and March 2014. Treatment consisted of C-ion RT with concurrent weekly cisplatin at a dose of 40 mg/m2 . In the phase 1 component, the total dose was escalated from 68.0 Gy (relative biological effectiveness [RBE]) to 74.4 Gy (RBE) to determine the maximum tolerated dose of C-ion RT. In the phase 2 component, the efficacy and safety of C-ion RT with concurrent chemotherapy were evaluated using the dose determined in the phase 1 component. The median follow-up duration was 30 months. Two patients did not receive chemotherapy because of anemia or leukocytopenia immediately prior to commencing treatment; 31 patients were analyzed. None of the patients developed dose-limiting toxicities. The recommended dose (RD) was determined to be 74.4 Gy (RBE). In the phase 2 component, two patients developed Grade 3-4 toxicities in the gastrointestinal tract, due to repeated laser coagulation or peritonitis caused by appendicitis. In the patients treated with the RD, the 2-year local control, progression-free survival, and overall survival rates were 71%, 56%, and 88%, respectively. C-ion RT with concurrent weekly cisplatin was well tolerated in patients with locally advanced uterine cervical adenocarcinoma. Our findings support further investigations into the efficacy of this strategy.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"John Wiley & Sons Ltd"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":" 29341491","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1002/cam4.1305 ","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-7634 ","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Okonogi, Noriyuki"}],"nameIdentifiers":[{"nameIdentifier":"488144","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakatsuki, Masaru"}],"nameIdentifiers":[{"nameIdentifier":"488145","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Shingo"}],"nameIdentifiers":[{"nameIdentifier":"488146","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Karasawa, Kumiko"}],"nameIdentifiers":[{"nameIdentifier":"488147","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kiyohara, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"488148","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shiba, Shintaro"}],"nameIdentifiers":[{"nameIdentifier":"488149","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi, Daijiro"}],"nameIdentifiers":[{"nameIdentifier":"488150","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakano, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"488151","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamada, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"488152","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Syozu, Makio"}],"nameIdentifiers":[{"nameIdentifier":"488153","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小此木 範之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"488154","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"若月 優","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"488155","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤 眞吾","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"488156","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"唐澤 久美子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"488157","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"清原 浩樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"488158","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柴 慎太郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"488159","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小林 大二郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"488160","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中野 隆史","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"488161","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"488162","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生水 真紀夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"488163","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Clinical outcomes of carbon ion radiotherapy with concurrent chemotherapy for locally advanced uterine cervical adenocarcinoma in a phase 1/2 clinical trial (Protocol 1001).","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Clinical outcomes of carbon ion radiotherapy with concurrent chemotherapy for locally advanced uterine cervical adenocarcinoma in a phase 1/2 clinical trial (Protocol 1001)."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-03-05"},"publish_date":"2018-03-05","publish_status":"0","recid":"48551","relation_version_is_last":true,"title":["Clinical outcomes of carbon ion radiotherapy with concurrent chemotherapy for locally advanced uterine cervical adenocarcinoma in a phase 1/2 clinical trial (Protocol 1001)."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:26:53.486993+00:00"}