WEKO3
アイテム
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Here we sought to establish a simultaneous approach for quantifying both myocardial blood flow (MBF) and the SNS from a single HED PET scan.\nMETHODS:\nTen controls and 13 patients with suspected cardiac disease were enrolled. The inflow rate of 11C-HED (K1) was obtained using a one-tissue-compartment model. We compared this rate with the MBF derived from 15O-H2O PET. In the controls, the relationship between K 1 from 11C-HED PET and the MBF from 15O-H2O PET was linked by the Renkin-Crone model.\nRESULTS:\nThe relationship between K 1 from 11C-HED PET and the MBF from 15O-H2O PET from the controls\u0027 data was approximated as follows: K 1 = (1 - 0.891 * exp(- 0.146/MBF)) * MBF. In the validation set, the correlation coefficient demonstrated a significantly high relationship for both the whole left ventricle (r = 0.95, P \u003c 0.001) and three coronary territories (left anterior descending artery: r = 0.96, left circumflex artery: r = 0.81, right coronary artery: r = 0.86; P \u003c 0.001, respectively).\nCONCLUSION:\n11C-HED can simultaneously estimate MBF and sympathetic nervous function without requiring an additional MBF scan for assessing mismatch areas between MBF and SNS.", "subitem_description_type": "Abstract"}]}, "item_8_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Springer"}]}, "item_8_relation_13": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "29270771", "subitem_relation_type_select": "PMID"}}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1007/s12350-017-1140-4", "subitem_relation_type_select": "DOI"}}]}, "item_8_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://link.springer.com/article/10.1007/s12350-017-1140-4", "subitem_relation_type_select": "URI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1532-6551", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hiroshima, Yuji"}], "nameIdentifiers": [{"nameIdentifier": "796024", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Manabe, Osamu"}], "nameIdentifiers": [{"nameIdentifier": "796025", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Naya, Masanao"}], "nameIdentifiers": [{"nameIdentifier": "796026", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tomiyama, Yuuki"}], "nameIdentifiers": [{"nameIdentifier": "796027", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Magota, Keiichi"}], "nameIdentifiers": [{"nameIdentifier": "796028", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Obara, Masahiko"}], "nameIdentifiers": [{"nameIdentifier": "796029", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aikawa, Tadao"}], "nameIdentifiers": [{"nameIdentifier": "796030", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Noriko, Oyama-Manabe"}], "nameIdentifiers": [{"nameIdentifier": "796031", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshinaga, Keiichiro"}], "nameIdentifiers": [{"nameIdentifier": "796032", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirata, Kenji"}], "nameIdentifiers": [{"nameIdentifier": "796033", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kroenke, Markus"}], "nameIdentifiers": [{"nameIdentifier": "796034", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tamaki, Nagara"}], "nameIdentifiers": [{"nameIdentifier": "796035", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Katoh, Chietsugu"}], "nameIdentifiers": [{"nameIdentifier": "796036", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshinaga, Keiichiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "796037", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Quantification of myocardial blood flow with 11C-hydroxyephedrine dynamic PET: comparison with 15O-H2O PET.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Quantification of myocardial blood flow with 11C-hydroxyephedrine dynamic PET: comparison with 15O-H2O PET."}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/48541", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-12-27"}, "publish_date": "2017-12-27", "publish_status": "0", "recid": "48541", "relation": {}, "relation_version_is_last": true, "title": ["Quantification of myocardial blood flow with 11C-hydroxyephedrine dynamic PET: comparison with 15O-H2O PET."], "weko_shared_id": -1}
Quantification of myocardial blood flow with 11C-hydroxyephedrine dynamic PET: comparison with 15O-H2O PET.
https://repo.qst.go.jp/records/48541
https://repo.qst.go.jp/records/4854102e788ce-5d1d-4667-9cd1-38a4f86169ec
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-12-27 | |||||
タイトル | ||||||
タイトル | Quantification of myocardial blood flow with 11C-hydroxyephedrine dynamic PET: comparison with 15O-H2O PET. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Hiroshima, Yuji
× Hiroshima, Yuji× Manabe, Osamu× Naya, Masanao× Tomiyama, Yuuki× Magota, Keiichi× Obara, Masahiko× Aikawa, Tadao× Noriko, Oyama-Manabe× Yoshinaga, Keiichiro× Hirata, Kenji× Kroenke, Markus× Tamaki, Nagara× Katoh, Chietsugu× Yoshinaga, Keiichiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | BACKGROUND: 11C-hydroxyephedrine (HED) PET has been used to evaluate the myocardial sympathetic nervous system (SNS). Here we sought to establish a simultaneous approach for quantifying both myocardial blood flow (MBF) and the SNS from a single HED PET scan. METHODS: Ten controls and 13 patients with suspected cardiac disease were enrolled. The inflow rate of 11C-HED (K1) was obtained using a one-tissue-compartment model. We compared this rate with the MBF derived from 15O-H2O PET. In the controls, the relationship between K 1 from 11C-HED PET and the MBF from 15O-H2O PET was linked by the Renkin-Crone model. RESULTS: The relationship between K 1 from 11C-HED PET and the MBF from 15O-H2O PET from the controls' data was approximated as follows: K 1 = (1 - 0.891 * exp(- 0.146/MBF)) * MBF. In the validation set, the correlation coefficient demonstrated a significantly high relationship for both the whole left ventricle (r = 0.95, P < 0.001) and three coronary territories (left anterior descending artery: r = 0.96, left circumflex artery: r = 0.81, right coronary artery: r = 0.86; P < 0.001, respectively). CONCLUSION: 11C-HED can simultaneously estimate MBF and sympathetic nervous function without requiring an additional MBF scan for assessing mismatch areas between MBF and SNS. |
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書誌情報 |
Journal of Nuclear Cardiology 発行日 2017-11 |
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出版者 | ||||||
出版者 | Springer | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1532-6551 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 29270771 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s12350-017-1140-4 | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://link.springer.com/article/10.1007/s12350-017-1140-4 |