WEKO3
アイテム
{"_buckets": {"deposit": "8b828abd-48f7-41ca-ba3a-c808e33ef4cf"}, "_deposit": {"created_by": 1, "id": "48363", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "48363"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00048363", "sets": ["1"]}, "author_link": ["486075", "486083", "486085", "486074", "486079", "486076", "486073", "486072", "486084", "486077", "486070", "486071", "486078", "486081", "486082", "486086", "486069", "486080"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "14945-9", "bibliographicPageStart": "14945-1", "bibliographicVolumeNumber": "7", "bibliographic_titles": [{"bibliographic_title": "Scientific Reports"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Metabotropic glutamate receptor subtype 1 (mGluR1) is a crucial pharmacological target for\nseveral CNS disorders. In this study, we aimed to monitor in vivo regional changes of\nmGluR1 related to neuroinflammation in the brains of rats after pilocarpine-induced status\nepilepticus (PISE) using longitudinal positron emission tomography (PET). PISE was induced\nin rats by administering lithium chloride, followed by repeated pilocarpine hydrochloride\ntreatments. PET assessments were conducted using\nN-[4-[6-(isopropylamino)-pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methyl-4-[11C]methylbenzamid\ne ([11C]ITDM), a selective radioligand for mGluR1, and\nN-benzyl-N-[11C]methyl-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide\n([11C]DAC), a selective translocator protein PET ligand for neuroinflammation monitoring.\nPET scans were conducted on PISE rats at 1 day (acute), 1 week (subacute) and 3 weeks\n(chronic) after repeated seizures. PET with [11C]ITDM showed significant decreases of\nmGluR1 availability (BPND) in the thalamus and hippocampus after PISE over the chronic\nperiod. Conversely, PET with [11C]DAC exhibited a significant increase of radioactive uptake\nin the forebrain after the acute period, especially in the thalamus. These conflicting changes in\nthe thalamus indicated negative correlation. In conclusion, PET with [11C]ITDM could\nsuccessfully visualize hippocampal and thalamic declines of mGluR1 related to\nneuroinflammation, which would help further understanding for mGluR1 functions in\nneuroexcitotoxicity.", "subitem_description_type": "Abstract"}]}, "item_8_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": " Macmillan Publishers Limited, part of Springer Nature"}]}, "item_8_relation_13": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "29097780", "subitem_relation_type_select": "PMID"}}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1038/s41598-017-15015-2", "subitem_relation_type_select": "DOI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2045-2322", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yamasaki, Tomoteru"}], "nameIdentifiers": [{"nameIdentifier": "486069", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujinaga, Masayuki"}], "nameIdentifiers": [{"nameIdentifier": "486070", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mori, Wakana"}], "nameIdentifiers": [{"nameIdentifier": "486071", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Yiding"}], "nameIdentifiers": [{"nameIdentifier": "486072", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wakizaka, Hidekatsu"}], "nameIdentifiers": [{"nameIdentifier": "486073", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nengaki, Nobuki"}], "nameIdentifiers": [{"nameIdentifier": "486074", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Xie, Lin"}], "nameIdentifiers": [{"nameIdentifier": "486075", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hatori, Akiko"}], "nameIdentifiers": [{"nameIdentifier": "486076", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Ming-Rong"}], "nameIdentifiers": [{"nameIdentifier": "486077", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "山崎 友照", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "486078", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "藤永 雅之", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "486079", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "森 若菜", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "486080", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "張 一鼎", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "486081", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "脇坂 秀克", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "486082", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "念垣 信樹", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "486083", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "謝 琳", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "486084", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "羽鳥 晶子", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "486085", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "張 明栄", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "486086", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "In Vivo Monitoring for Regional Changes of Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Pilocarpine-Induced Epileptic Rat Brain by Small-Animal PET", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "In Vivo Monitoring for Regional Changes of Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Pilocarpine-Induced Epileptic Rat Brain by Small-Animal PET"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/48363", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-11-16"}, "publish_date": "2017-11-16", "publish_status": "0", "recid": "48363", "relation": {}, "relation_version_is_last": true, "title": ["In Vivo Monitoring for Regional Changes of Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Pilocarpine-Induced Epileptic Rat Brain by Small-Animal PET"], "weko_shared_id": -1}
In Vivo Monitoring for Regional Changes of Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Pilocarpine-Induced Epileptic Rat Brain by Small-Animal PET
https://repo.qst.go.jp/records/48363
https://repo.qst.go.jp/records/48363286a0b54-3c7d-4dba-a39b-635035d1f27e
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-11-16 | |||||
タイトル | ||||||
タイトル | In Vivo Monitoring for Regional Changes of Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Pilocarpine-Induced Epileptic Rat Brain by Small-Animal PET | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Yamasaki, Tomoteru
× Yamasaki, Tomoteru× Fujinaga, Masayuki× Mori, Wakana× Zhang, Yiding× Wakizaka, Hidekatsu× Nengaki, Nobuki× Xie, Lin× Hatori, Akiko× Zhang, Ming-Rong× 山崎 友照× 藤永 雅之× 森 若菜× 張 一鼎× 脇坂 秀克× 念垣 信樹× 謝 琳× 羽鳥 晶子× 張 明栄 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Metabotropic glutamate receptor subtype 1 (mGluR1) is a crucial pharmacological target for several CNS disorders. In this study, we aimed to monitor in vivo regional changes of mGluR1 related to neuroinflammation in the brains of rats after pilocarpine-induced status epilepticus (PISE) using longitudinal positron emission tomography (PET). PISE was induced in rats by administering lithium chloride, followed by repeated pilocarpine hydrochloride treatments. PET assessments were conducted using N-[4-[6-(isopropylamino)-pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methyl-4-[11C]methylbenzamid e ([11C]ITDM), a selective radioligand for mGluR1, and N-benzyl-N-[11C]methyl-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide ([11C]DAC), a selective translocator protein PET ligand for neuroinflammation monitoring. PET scans were conducted on PISE rats at 1 day (acute), 1 week (subacute) and 3 weeks (chronic) after repeated seizures. PET with [11C]ITDM showed significant decreases of mGluR1 availability (BPND) in the thalamus and hippocampus after PISE over the chronic period. Conversely, PET with [11C]DAC exhibited a significant increase of radioactive uptake in the forebrain after the acute period, especially in the thalamus. These conflicting changes in the thalamus indicated negative correlation. In conclusion, PET with [11C]ITDM could successfully visualize hippocampal and thalamic declines of mGluR1 related to neuroinflammation, which would help further understanding for mGluR1 functions in neuroexcitotoxicity. |
|||||
書誌情報 |
Scientific Reports 巻 7, 号 1, p. 14945-1-14945-9, 発行日 2017-11 |
|||||
出版者 | ||||||
出版者 | Macmillan Publishers Limited, part of Springer Nature | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2045-2322 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 29097780 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1038/s41598-017-15015-2 |