@article{oai:repo.qst.go.jp:00048363,
 author = {Yamasaki, Tomoteru and Fujinaga, Masayuki and Mori, Wakana and Zhang, Yiding and Wakizaka, Hidekatsu and Nengaki, Nobuki and Xie, Lin and Hatori, Akiko and Zhang, Ming-Rong and 山崎 友照 and 藤永 雅之 and 森 若菜 and 張 一鼎 and 脇坂 秀克 and 念垣 信樹 and 謝 琳 and 羽鳥 晶子 and 張 明栄},
 issue = {1},
 journal = {Scientific Reports},
 month = {Nov},
 note = {Metabotropic glutamate receptor subtype 1 (mGluR1) is a crucial pharmacological target for
several CNS disorders. In this study, we aimed to monitor in vivo regional changes of
mGluR1 related to neuroinflammation in the brains of rats after pilocarpine-induced status
epilepticus (PISE) using longitudinal positron emission tomography (PET). PISE was induced
in rats by administering lithium chloride, followed by repeated pilocarpine hydrochloride
treatments. PET assessments were conducted using
N-[4-[6-(isopropylamino)-pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methyl-4-[11C]methylbenzamid
e ([11C]ITDM), a selective radioligand for mGluR1, and
N-benzyl-N-[11C]methyl-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide
([11C]DAC), a selective translocator protein PET ligand for neuroinflammation monitoring.
PET scans were conducted on PISE rats at 1 day (acute), 1 week (subacute) and 3 weeks
(chronic) after repeated seizures. PET with [11C]ITDM showed significant decreases of
mGluR1 availability (BPND) in the thalamus and hippocampus after PISE over the chronic
period. Conversely, PET with [11C]DAC exhibited a significant increase of radioactive uptake
in the forebrain after the acute period, especially in the thalamus. These conflicting changes in
the thalamus indicated negative correlation. In conclusion, PET with [11C]ITDM could
successfully visualize hippocampal and thalamic declines of mGluR1 related to
neuroinflammation, which would help further understanding for mGluR1 functions in
neuroexcitotoxicity.},
 pages = {14945-1--14945-9},
 title = {In Vivo Monitoring for Regional Changes of Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Pilocarpine-Induced Epileptic Rat Brain by Small-Animal PET},
 volume = {7},
 year = {2017}
}