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We retrospectively evaluated the efficacy and safety of\ncarbon-ion radiation therapy (C-ion RT) for HN adenocarcinoma in institutions in\nJapan.\nMethods and Materials: HN adenocarcinoma patients with N0M0 or N1M0 disease\nwho were treated with C-ion RT at institutions in Japan between November 2003\nand December 2014 were analyzed retrospectively. We enrolled 47 patients (30 male\nand 17 female patients; median age, 60 years) with HN adenocarcinoma.\nResults: Primary sites included the nasal and paranasal sinus in 21 patients, orbit in\n11, salivary grand in 7, oral cavity and pharynx in 6, and acoustic organ in 2.\nThirty-two patients had T4 tumors, 6 had T3, and 6 had T2. Forty-five patients\nreceived a diagnosis of N0 disease, whereas 2 had N1 disease. The median total dose\nof C-ion RT and the number of fractions were 64.0 Gy (relative biological effectiveness)\nand 16 fractions, respectively. The median follow-up period was 51 months\n(range, 6-118 months). The 2- and 5-year overall survival rates were 87.9% and\n60.4%, respectively, and the 2- and 5-year local control rates were 83.3% and\n79.3%, respectively. Multivariate analysis showed that operability (patients with\noperable tumors) (PZ.045) and fractionation (16 fractions) (PZ.010) were significant independent prognostic factors for better overall survival. No grade 5 late morbidities\nwere observed. Grade 4 late morbidities were observed in 4 patients, and all of\nthese grade 4 morbidities were visual impairments. 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A Multicenter Study of Carbon-Ion Radiation Therapy for Head and Neck Adenocarcinoma
https://repo.qst.go.jp/records/48357
https://repo.qst.go.jp/records/4835755e67e9e-15ef-4f4e-86a3-da6f69f9aa39
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-11-02 | |||||
タイトル | ||||||
タイトル | A Multicenter Study of Carbon-Ion Radiation Therapy for Head and Neck Adenocarcinoma | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Saitoh, Jun-ichi
× Saitoh, Jun-ichi× Koto, Masashi× Demizu, Yusuke× Suefuji, Hiroaki× Ohno, Tatsuya× Tsuji, Hiroshi× Okimoto, Tomoaki× Shioyama, Yoshiyuki× Nemoto, Kenji× Nakano, Takashi× Kamada, Tadashi× 小藤 昌志× 末藤 大明× 大野 達也× 辻 比呂志× 沖本 智昭× 塩山 善之× 根本 建二× 中野 隆史× 鎌田 正 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Purpose: Head and neck (HN) adenocarcinoma is rare, and to date, there have been no reports of prospective studies. We retrospectively evaluated the efficacy and safety of carbon-ion radiation therapy (C-ion RT) for HN adenocarcinoma in institutions in Japan. Methods and Materials: HN adenocarcinoma patients with N0M0 or N1M0 disease who were treated with C-ion RT at institutions in Japan between November 2003 and December 2014 were analyzed retrospectively. We enrolled 47 patients (30 male and 17 female patients; median age, 60 years) with HN adenocarcinoma. Results: Primary sites included the nasal and paranasal sinus in 21 patients, orbit in 11, salivary grand in 7, oral cavity and pharynx in 6, and acoustic organ in 2. Thirty-two patients had T4 tumors, 6 had T3, and 6 had T2. Forty-five patients received a diagnosis of N0 disease, whereas 2 had N1 disease. The median total dose of C-ion RT and the number of fractions were 64.0 Gy (relative biological effectiveness) and 16 fractions, respectively. The median follow-up period was 51 months (range, 6-118 months). The 2- and 5-year overall survival rates were 87.9% and 60.4%, respectively, and the 2- and 5-year local control rates were 83.3% and 79.3%, respectively. Multivariate analysis showed that operability (patients with operable tumors) (PZ.045) and fractionation (16 fractions) (PZ.010) were significant independent prognostic factors for better overall survival. No grade 5 late morbidities were observed. Grade 4 late morbidities were observed in 4 patients, and all of these grade 4 morbidities were visual impairments. All 4 patients with grade 4 visual impairment had T4 tumors in the nasopharynx or paranasal sinuses, which implied inoperable tumors with orbital or brain invasion. |
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書誌情報 |
Int J Radiation Oncol Biol Phys 巻 99, 号 2, p. 442-449, 発行日 2017-05 |
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出版者 | ||||||
出版者 | Elsevier Inc | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0360-3016 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 28871995 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.ijrobp.2017.04.032 | |||||
関連サイト | ||||||
識別子タイプ | DOI | |||||
関連識別子 | http://dx.doi.org/10.1016/j.ijrobp.2017.04.032 | |||||
関連名称 | http://dx.doi.org/10.1016/j.ijrobp.2017.04.032 |