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Regional hypoplasia of somatosensory cortex in growth-retarded mice (grt/grt).
https://repo.qst.go.jp/records/47895
https://repo.qst.go.jp/records/4789559549baf-8e4c-410e-bec7-519fb6e79946
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-04-28 | |||||
| タイトル | ||||||
| タイトル | Regional hypoplasia of somatosensory cortex in growth-retarded mice (grt/grt). | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sawada, Kazuhiko
× Sawada, Kazuhiko× Saito, Shigeyoshi× Sugasawa, Akari× Sato, Chika× Aoyama, Junya× Ohara, Naoko× Horiuchi-Hirose, Miwa× Kobayashi, Tetsuya× 齋藤 茂芳× 佐藤 千佳 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Growth-retarded mouse (grt/grt) is a spontaneous mutant that is known as an animal model for primary congenital hypothyroidism caused by resistance to TSH signaling. The regional pattern of cerebral cortical hypoplasia was characterized in grt/grt mice. Ex vivo computed tomography (CT)-based volumetry was examined in four regions of the cerebral cortex, i.e., prefrontal, frontal, parietal and occipito-temporal regions, which were demarcated by structural landmarks on coronal CT images. A region-specific reduced volume of the parietal cortical region covering most of the somatosensory cortex was noted in grt/grt mice rather than in both heterozygous (grt/+) and wild-type (+/+) mice. We concluded that the cortical hypoplasia in grt/grt was seen in identical cortical regions corresponding to human congenital hypothyroidism. This article is protected by copyright. All rights reserved. | |||||
| 書誌情報 |
Congenital anomalies 巻 56, 号 4, p. 180-183, 発行日 2016-02 |
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| 出版者 | ||||||
| 出版者 | Wiley on behalf of the Japanese Teratology Society | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0914-3505 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 26915353 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1111/cga.12161 | |||||
