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Non-invasive Measurement of Melanin-Derived Radicals in Living Mouse Tail Using X-band EPR
https://repo.qst.go.jp/records/47631
https://repo.qst.go.jp/records/47631e05c94ec-85e0-49b2-9ed8-755731c36d81
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Ogawa.Y.2016.J.Clin.Biochem.Nutr.59.160-164.pdf (516.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-02-02 | |||||
| タイトル | ||||||
| タイトル | Non-invasive Measurement of Melanin-Derived Radicals in Living Mouse Tail Using X-band EPR | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Ogawa, Yukihiro
× Ogawa, Yukihiro× Ueno, Megumi× Sekine-Suzuki, Emiko× Nakanishi, Ikuo× Matsumoto, Ken-ichiro× Fujisaki, Shingo× 小川 幸大× 上野 恵美× 関根 絵美子× 中西 郁夫× 松本 謙一郎 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The aim of this experiment is to measure in vivo generation of melanin-derived radicals non-invasively, as a quantifiable index of radio-biological effect. Melanin-derived radicals in a living intact mouse tail tip were non-invasively measured in very simple way using an X-band electron paramagnetic resonance spectrometer. Colored mouse strains, C57BL/6NCr, BDF1, and C3H/He, has clear EPR signal corresponding to melanin-derived radicals in the tail tip; however, albino mouse strains, BALB/cCr, ddY, ICR, has no EPR signals. An X-ray fraction of 2 Gy/day (1 Gy/min) was repeatedly irradiated to a C3H/He mouse tail skin every Monday to Friday for 4 weeks. In comparison to before starting irradiation, the C3H/He mouse tail skin became darker, like a suntan. The melanin-derived radicals in C3H/He mouse tail skin was increased in association with X-ray fractions. Melanin-derived radicals in mouse tail skin can be readily and chronologically measurable by using X-band EPR spectrometer, and can be a marker for a radiobiological effect in the skin. | |||||
| 書誌情報 |
Journal of Clinical Biochemistry and Nutrition 巻 59, 号 3, p. 160-164, 発行日 2016-11 |
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| 出版者 | ||||||
| 出版者 | 日本酸化ストレス学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0912-0009 | |||||
