WEKO3
アイテム
{"_buckets": {"deposit": "a6fa2689-f729-434e-9f11-f1dea8718661"}, "_deposit": {"created_by": 1, "id": "47277", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "47277"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00047277", "sets": ["1"]}, "author_link": ["472867", "472858", "472861", "472866", "472860", "472854", "472857", "472865", "472864", "472859", "472853", "472856", "472862", "472863", "472855"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2015-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageEnd": "5921", "bibliographicPageStart": "5913", "bibliographicVolumeNumber": "9", "bibliographic_titles": [{"bibliographic_title": "ACS Nano"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Gadolinium (Gd) chelates-loaded nanocarriers have high potential for achieving magnetic resonance imaging (MRI)-guided Gd neutron capture therapy (GdNCT) of tumors. Herein, we developed calcium phosphate micelles hybridized with PEG-polyanion block copolymers, and incorporated with the clinical MRI contrast agent Gd-diethylenetriaminepentaacetic acid (Gd-DTPA/CaP). The Gd-DTPA/CaP were nontoxic to cancer cells at the concentration of 100 μM based on Gd-DTPA, while over 50% of the cancer cells were killed by thermal neutron irradiation at this concentration. Moreover, the Gd-DTPA/CaP showed a dramatically increased accumulation of Gd-DTPA in tumors, leading to the selective contrast enhancement of tumor tissues for precise tumor location by MRI. The enhanced tumor-to-blood distribution ratio of Gd-DTPA/CaP resulted in the effective suppression of tumor growth without loss of body weight, indicating the potential of Gd-DTPA/CaP for safe cancer treatment.", "subitem_description_type": "Abstract"}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1021/acsnano.5b00532", "subitem_relation_type_select": "DOI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0002-7863", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Mi, Peng"}], "nameIdentifiers": [{"nameIdentifier": "472853", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Dewi, Novriana"}], "nameIdentifiers": [{"nameIdentifier": "472854", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yanagie, Hironobu"}], "nameIdentifiers": [{"nameIdentifier": "472855", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kokuryo, Daisuke"}], "nameIdentifiers": [{"nameIdentifier": "472856", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Minoru"}], "nameIdentifiers": [{"nameIdentifier": "472857", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sakurai, Yoshinori"}], "nameIdentifiers": [{"nameIdentifier": "472858", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Li, Yanmin"}], "nameIdentifiers": [{"nameIdentifier": "472859", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aoki, Ichio"}], "nameIdentifiers": [{"nameIdentifier": "472860", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahashi, Hiroyuki"}], "nameIdentifiers": [{"nameIdentifier": "472861", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Cabral, Horacio"}], "nameIdentifiers": [{"nameIdentifier": "472862", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishiyama, Nobuhiro"}], "nameIdentifiers": [{"nameIdentifier": "472863", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kataoka, Kazunori"}], "nameIdentifiers": [{"nameIdentifier": "472864", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "國領 大介", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472865", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "櫻井 良憲", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472866", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "青木 伊知男", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "472867", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Hybrid Calcium Phosphate-Polymeric Micelles Incorporating Gadolinium Chelates for Imaging-Guided Gadolinium Neutron Capture Tumor Therapy.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Hybrid Calcium Phosphate-Polymeric Micelles Incorporating Gadolinium Chelates for Imaging-Guided Gadolinium Neutron Capture Tumor Therapy."}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/47277", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-09-15"}, "publish_date": "2015-09-15", "publish_status": "0", "recid": "47277", "relation": {}, "relation_version_is_last": true, "title": ["Hybrid Calcium Phosphate-Polymeric Micelles Incorporating Gadolinium Chelates for Imaging-Guided Gadolinium Neutron Capture Tumor Therapy."], "weko_shared_id": -1}
Hybrid Calcium Phosphate-Polymeric Micelles Incorporating Gadolinium Chelates for Imaging-Guided Gadolinium Neutron Capture Tumor Therapy.
https://repo.qst.go.jp/records/47277
https://repo.qst.go.jp/records/472771098616e-3b9c-4486-a13a-cd7fe84a195b
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2015-09-15 | |||||
タイトル | ||||||
タイトル | Hybrid Calcium Phosphate-Polymeric Micelles Incorporating Gadolinium Chelates for Imaging-Guided Gadolinium Neutron Capture Tumor Therapy. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Mi, Peng
× Mi, Peng× Dewi, Novriana× Yanagie, Hironobu× Kokuryo, Daisuke× Suzuki, Minoru× Sakurai, Yoshinori× Li, Yanmin× Aoki, Ichio× Takahashi, Hiroyuki× Cabral, Horacio× Nishiyama, Nobuhiro× Kataoka, Kazunori× 國領 大介× 櫻井 良憲× 青木 伊知男 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Gadolinium (Gd) chelates-loaded nanocarriers have high potential for achieving magnetic resonance imaging (MRI)-guided Gd neutron capture therapy (GdNCT) of tumors. Herein, we developed calcium phosphate micelles hybridized with PEG-polyanion block copolymers, and incorporated with the clinical MRI contrast agent Gd-diethylenetriaminepentaacetic acid (Gd-DTPA/CaP). The Gd-DTPA/CaP were nontoxic to cancer cells at the concentration of 100 μM based on Gd-DTPA, while over 50% of the cancer cells were killed by thermal neutron irradiation at this concentration. Moreover, the Gd-DTPA/CaP showed a dramatically increased accumulation of Gd-DTPA in tumors, leading to the selective contrast enhancement of tumor tissues for precise tumor location by MRI. The enhanced tumor-to-blood distribution ratio of Gd-DTPA/CaP resulted in the effective suppression of tumor growth without loss of body weight, indicating the potential of Gd-DTPA/CaP for safe cancer treatment. | |||||
書誌情報 |
ACS Nano 巻 9, 号 6, p. 5913-5921, 発行日 2015-06 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0002-7863 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1021/acsnano.5b00532 |