{"created":"2023-05-15T14:36:41.965390+00:00","id":47277,"links":{},"metadata":{"_buckets":{"deposit":"a6fa2689-f729-434e-9f11-f1dea8718661"},"_deposit":{"created_by":1,"id":"47277","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47277"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047277","sets":["1"]},"author_link":["472867","472858","472861","472866","472860","472854","472857","472865","472864","472859","472853","472856","472862","472863","472855"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"5921","bibliographicPageStart":"5913","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"ACS Nano"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Gadolinium (Gd) chelates-loaded nanocarriers have high potential for achieving magnetic resonance imaging (MRI)-guided Gd neutron capture therapy (GdNCT) of tumors. Herein, we developed calcium phosphate micelles hybridized with PEG-polyanion block copolymers, and incorporated with the clinical MRI contrast agent Gd-diethylenetriaminepentaacetic acid (Gd-DTPA/CaP). The Gd-DTPA/CaP were nontoxic to cancer cells at the concentration of 100 μM based on Gd-DTPA, while over 50% of the cancer cells were killed by thermal neutron irradiation at this concentration. Moreover, the Gd-DTPA/CaP showed a dramatically increased accumulation of Gd-DTPA in tumors, leading to the selective contrast enhancement of tumor tissues for precise tumor location by MRI. The enhanced tumor-to-blood distribution ratio of Gd-DTPA/CaP resulted in the effective suppression of tumor growth without loss of body weight, indicating the potential of Gd-DTPA/CaP for safe cancer treatment.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1021/acsnano.5b00532","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0002-7863","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mi, Peng"}],"nameIdentifiers":[{"nameIdentifier":"472853","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Dewi, Novriana"}],"nameIdentifiers":[{"nameIdentifier":"472854","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yanagie, Hironobu"}],"nameIdentifiers":[{"nameIdentifier":"472855","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kokuryo, Daisuke"}],"nameIdentifiers":[{"nameIdentifier":"472856","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Minoru"}],"nameIdentifiers":[{"nameIdentifier":"472857","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakurai, Yoshinori"}],"nameIdentifiers":[{"nameIdentifier":"472858","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Li, Yanmin"}],"nameIdentifiers":[{"nameIdentifier":"472859","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio"}],"nameIdentifiers":[{"nameIdentifier":"472860","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"472861","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Cabral, Horacio"}],"nameIdentifiers":[{"nameIdentifier":"472862","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishiyama, Nobuhiro"}],"nameIdentifiers":[{"nameIdentifier":"472863","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kataoka, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"472864","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"國領 大介","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"472865","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"櫻井 良憲","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"472866","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 伊知男","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"472867","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Hybrid Calcium Phosphate-Polymeric Micelles Incorporating Gadolinium Chelates for Imaging-Guided Gadolinium Neutron Capture Tumor Therapy.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Hybrid Calcium Phosphate-Polymeric Micelles Incorporating Gadolinium Chelates for Imaging-Guided Gadolinium Neutron Capture Tumor Therapy."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-09-15"},"publish_date":"2015-09-15","publish_status":"0","recid":"47277","relation_version_is_last":true,"title":["Hybrid Calcium Phosphate-Polymeric Micelles Incorporating Gadolinium Chelates for Imaging-Guided Gadolinium Neutron Capture Tumor Therapy."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:41:44.575798+00:00"}