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MATERIALS AND METHODS: Patients with early breast cancer (stages 0-II and \u003c3 positive lymph nodes) who had undergone breast-conserving surgery were eligible for the HF-WBI study. HF-WBI was administered at 43.2 Gy in 16 fractions over 3.2 weeks to the whole breast with an additional tumor-bed boost of 8.1 Gy in 3 fractions over 3 days for positive surgical margins or those \u003c5 mm. CF-WBI was administered at 50 Gy in 25 fractions over 5 weeks to the whole breast with an additional tumor-bed boost of 16 Gy in 8 fractions over 1.4 weeks to 6 Gy in 3 fractions over 3 days, depending on margin status. RESULTS: From April 1, 2006, to December 31, 2010, 717 patients were registered and 734 breasts were treated by HF-WBI. In the same period, 381 patients and 393 breasts who matched the study criteria chose CF-WBI, so the total number of patients in this comparison was 1,098. Grade 2 acute skin reactions were observed for 24 patients (3 %) in the HF-WBI group and 53 patients (14 %) in the CF-WBI (p \u003c 0.001) group. The median follow-up period was 27 months. Two cases of intrabreast tumor recurrence were observed in each treatment group. Regional lymph node recurrence was observed in 1 HF-WBI patient and 2 CF-WBI patients. CONCLUSION: HF-WBI is superior to CF-WBI in terms of acute skin reaction and has the same short-term efficacy.", "subitem_description_type": "Abstract"}]}, "item_8_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Springer"}]}, "item_8_relation_13": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "22968629", "subitem_relation_type_select": "PMID"}}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1007/s12282-012-0406-6", "subitem_relation_type_select": "DOI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1340-6868", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Karasawa, Kumiko"}], "nameIdentifiers": [{"nameIdentifier": "465006", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kunogi, Hiroaki"}], "nameIdentifiers": [{"nameIdentifier": "465007", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirai, Takahisa"}], "nameIdentifiers": [{"nameIdentifier": "465008", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hojo, Hidehiro"}], "nameIdentifiers": [{"nameIdentifier": "465009", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirowatari, Hisako"}], "nameIdentifiers": [{"nameIdentifier": "465010", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Izawa, Hiromi"}], "nameIdentifiers": [{"nameIdentifier": "465011", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ito, Kana"}], "nameIdentifiers": [{"nameIdentifier": "465012", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sasai, Keisuke"}], "nameIdentifiers": [{"nameIdentifier": "465013", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawashima, Motohiro"}], "nameIdentifiers": [{"nameIdentifier": "465014", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Furuya, Tomohisa"}], "nameIdentifiers": [{"nameIdentifier": "465015", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sugimoto, Satoru"}], "nameIdentifiers": [{"nameIdentifier": "465016", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kurokawa, Chie"}], "nameIdentifiers": [{"nameIdentifier": "465017", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ozawa, Shuichi"}], "nameIdentifiers": [{"nameIdentifier": "465018", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saito, Mitsue"}], "nameIdentifiers": [{"nameIdentifier": "465019", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "唐澤 久美子", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "465020", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "平井 崇久", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "465021", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "川嶋 基敬", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "465022", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Comparison of hypofractionated and conventionally fractionated whole-breast irradiation for early breast cancer patients: a single-institute study of 1,098 patients.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Comparison of hypofractionated and conventionally fractionated whole-breast irradiation for early breast cancer patients: a single-institute study of 1,098 patients."}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/46646", "pubdate": {"attribute_name": "公開日", "attribute_value": "2013-11-27"}, "publish_date": "2013-11-27", "publish_status": "0", "recid": "46646", "relation": {}, "relation_version_is_last": true, "title": ["Comparison of hypofractionated and conventionally fractionated whole-breast irradiation for early breast cancer patients: a single-institute study of 1,098 patients."], "weko_shared_id": -1}
Comparison of hypofractionated and conventionally fractionated whole-breast irradiation for early breast cancer patients: a single-institute study of 1,098 patients.
https://repo.qst.go.jp/records/46646
https://repo.qst.go.jp/records/46646ce1de8ab-2cdb-4991-bb05-f9cb664cc72c
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-11-27 | |||||
タイトル | ||||||
タイトル | Comparison of hypofractionated and conventionally fractionated whole-breast irradiation for early breast cancer patients: a single-institute study of 1,098 patients. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Karasawa, Kumiko
× Karasawa, Kumiko× Kunogi, Hiroaki× Hirai, Takahisa× Hojo, Hidehiro× Hirowatari, Hisako× Izawa, Hiromi× Ito, Kana× Sasai, Keisuke× Kawashima, Motohiro× Furuya, Tomohisa× Sugimoto, Satoru× Kurokawa, Chie× Ozawa, Shuichi× Saito, Mitsue× 唐澤 久美子× 平井 崇久× 川嶋 基敬 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | PURPOSE: To evaluate the efficacy and safety of hypofractionated whole-breast irradiation (HF-WBI) compared with conventionally fractionated (CF) WBI. MATERIALS AND METHODS: Patients with early breast cancer (stages 0-II and <3 positive lymph nodes) who had undergone breast-conserving surgery were eligible for the HF-WBI study. HF-WBI was administered at 43.2 Gy in 16 fractions over 3.2 weeks to the whole breast with an additional tumor-bed boost of 8.1 Gy in 3 fractions over 3 days for positive surgical margins or those <5 mm. CF-WBI was administered at 50 Gy in 25 fractions over 5 weeks to the whole breast with an additional tumor-bed boost of 16 Gy in 8 fractions over 1.4 weeks to 6 Gy in 3 fractions over 3 days, depending on margin status. RESULTS: From April 1, 2006, to December 31, 2010, 717 patients were registered and 734 breasts were treated by HF-WBI. In the same period, 381 patients and 393 breasts who matched the study criteria chose CF-WBI, so the total number of patients in this comparison was 1,098. Grade 2 acute skin reactions were observed for 24 patients (3 %) in the HF-WBI group and 53 patients (14 %) in the CF-WBI (p < 0.001) group. The median follow-up period was 27 months. Two cases of intrabreast tumor recurrence were observed in each treatment group. Regional lymph node recurrence was observed in 1 HF-WBI patient and 2 CF-WBI patients. CONCLUSION: HF-WBI is superior to CF-WBI in terms of acute skin reaction and has the same short-term efficacy. | |||||
書誌情報 |
Breast cancer (Tokyo, Japan) 発行日 2012-09 |
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出版者 | ||||||
出版者 | Springer | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1340-6868 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 22968629 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1007/s12282-012-0406-6 |