WEKO3
アイテム
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A preoperative, short-course, dose-escalation study was performed with fixed 8 fractions in 2 weeks. The dose of irradiation was increased by 5% increments from 30 grays equivalents (GyE) to 36.8 GyE. Surgery was to be performed 2 to 4 weeks after the completion of CIRT.\nRESULTS: The study enrolled 26 patients. At the time of restaging after CIRT, disease progression with distant metastasis or refusal ruled out 5 patients from surgery. Twenty-one of 26 patients (81%) patients underwent surgery. The pattern of initial disease progression was distant metastasis in 17 patients (65%) and regional recurrence in 2 patients (8%). No patients experienced local recurrence. The 5-year survival rates for all 26 patients and for those who underwent surgery were 42% and 52%, respectively.\nCONCLUSIONS: Preoperative, short-course CIRT followed by surgery is feasible and tolerable without unacceptable morbidity. Cancer 2013. \u0026copy; 2012 American Cancer Society.", "subitem_description_type": "Abstract"}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1002/cncr.27723", "subitem_relation_type_select": "DOI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0008-543X", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Shinoto, Makoto"}], "nameIdentifiers": [{"nameIdentifier": "464586", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamada, Shigeru"}], "nameIdentifiers": [{"nameIdentifier": "464587", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yasuda, Shigeo"}], "nameIdentifiers": [{"nameIdentifier": "464588", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Imada, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "464589", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shioyama, Yoshiyuki"}], "nameIdentifiers": [{"nameIdentifier": "464590", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hiroshi, Honda"}], "nameIdentifiers": [{"nameIdentifier": "464591", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kamada, Tadashi"}], "nameIdentifiers": [{"nameIdentifier": "464592", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsujii, Hirohiko"}], "nameIdentifiers": [{"nameIdentifier": "464593", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saisho, Hiromitsu"}], "nameIdentifiers": [{"nameIdentifier": "464594", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "et.al"}], "nameIdentifiers": [{"nameIdentifier": "464595", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "篠藤 誠", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "464596", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "山田 滋", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "464597", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "安田 茂雄", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "464598", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "今田 浩史", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "464599", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "塩山 善之", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "464600", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "本田 浩", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "464601", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "鎌田 正", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "464602", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "辻井 博彦", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "464603", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "税所 宏光", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "464604", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Phase 1 trial of preoperative, short-course carbon-ion radiotherapy for patients with resectable pancreatic cancer", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Phase 1 trial of preoperative, short-course carbon-ion radiotherapy for patients with resectable pancreatic cancer"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/46605", "pubdate": {"attribute_name": "公開日", "attribute_value": "2013-10-17"}, "publish_date": "2013-10-17", "publish_status": "0", "recid": "46605", "relation": {}, "relation_version_is_last": true, "title": ["Phase 1 trial of preoperative, short-course carbon-ion radiotherapy for patients with resectable pancreatic cancer"], "weko_shared_id": -1}
Phase 1 trial of preoperative, short-course carbon-ion radiotherapy for patients with resectable pancreatic cancer
https://repo.qst.go.jp/records/46605
https://repo.qst.go.jp/records/46605c2c41202-e10f-4c99-be70-ff661061bdfa
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-10-17 | |||||
タイトル | ||||||
タイトル | Phase 1 trial of preoperative, short-course carbon-ion radiotherapy for patients with resectable pancreatic cancer | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Shinoto, Makoto
× Shinoto, Makoto× Yamada, Shigeru× Yasuda, Shigeo× Imada, Hiroshi× Shioyama, Yoshiyuki× Hiroshi, Honda× Kamada, Tadashi× Tsujii, Hirohiko× Saisho, Hiromitsu× et.al× 篠藤 誠× 山田 滋× 安田 茂雄× 今田 浩史× 塩山 善之× 本田 浩× 鎌田 正× 辻井 博彦× 税所 宏光 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | BACKGROUND: The authors evaluated the tolerance and efficacy of carbon-ion radiotherapy (CIRT) as a short-course, preoperative treatment and determined the recommended dose needed to reduce the risk of postoperative local recurrence without excess injury to normal tissue. METHODS: Patients radiographically defined with potentially resectable pancreatic cancer were eligible. A preoperative, short-course, dose-escalation study was performed with fixed 8 fractions in 2 weeks. The dose of irradiation was increased by 5% increments from 30 grays equivalents (GyE) to 36.8 GyE. Surgery was to be performed 2 to 4 weeks after the completion of CIRT. RESULTS: The study enrolled 26 patients. At the time of restaging after CIRT, disease progression with distant metastasis or refusal ruled out 5 patients from surgery. Twenty-one of 26 patients (81%) patients underwent surgery. The pattern of initial disease progression was distant metastasis in 17 patients (65%) and regional recurrence in 2 patients (8%). No patients experienced local recurrence. The 5-year survival rates for all 26 patients and for those who underwent surgery were 42% and 52%, respectively. CONCLUSIONS: Preoperative, short-course CIRT followed by surgery is feasible and tolerable without unacceptable morbidity. Cancer 2013. © 2012 American Cancer Society. |
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書誌情報 |
Cancer 巻 119, 号 1, p. 45-51, 発行日 2012-06 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0008-543X | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1002/cncr.27723 |