WEKO3
アイテム
{"_buckets": {"deposit": "d0eca7ff-f9b9-4ce6-9158-1ec5b16aa19b"}, "_deposit": {"created_by": 1, "id": "46598", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "46598"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00046598", "sets": ["1"]}, "author_link": ["464502", "464500", "464499", "464507", "464495", "464506", "464497", "464503", "464504", "464505", "464508", "464509", "464498", "464496", "464501"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2013-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1021", "bibliographicPageStart": "20120302", "bibliographicVolumeNumber": "86", "bibliographic_titles": [{"bibliographic_title": "British Journal of Radiology"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Objective: To detect the radiosensitivity of intratumour quiescent (Q) cells unlabelled with pimonidazole to accelerated carbon ion beams and the boron neutron capture reaction (BNCR).\nMethods: EL4 tumour-bearing C57BL/J mice received 5-bromo-29-deoxyuridine (BrdU)\ncontinuously to label all intratumour proliferating (P) cells. After the administration of pimonidazole, tumours were irradiated with c-rays, accelerated carbon ion beams or reactor neutron beams with the prior administration of a 10B-carrier. Responses of intratumour Q and total (P+Q) cell populations were assessed based on frequencies of micronucleation and apoptosis using immunofluorescence staining for BrdU. The response of pimonidazole-unlabelled tumour cells was assessed by means of apoptosis frequency using immunofluorescence staining for pimonidazole.\nResults: Following c-ray irradiation, the pimonidazole-unlabelled tumour cell fraction showed significantly enhanced radiosensitivity compared with the whole tumour cell fraction, more remarkably in the Q than total cell populations. However, a significantly greater decrease in radiosensitivity in the pimonidazole-unlabelled cell fraction, evaluated using a delayed assay or a decrease in radiation dose rate, was more clearly observed among the Q than total cells. These changes in radiosensitivity were suppressed following carbon ion beam and neutron beam-only irradiaton. In the BNCR, the use of a 10B-carrier, especially L-para-boronophenylalanine-10B, enhanced the sensitivity of the pimonidazole-unlabelled cells more clearly in the Q than total cells.\nConclusion: The radiosensitivity of the pimonidazole-unlabelled cell fraction depends on the quality of radiation delivered and characteristics of the 10B-carrier used in the BNCR.", "subitem_description_type": "Abstract"}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1259/bjr.20120302", "subitem_relation_type_select": "DOI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0007-1285", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Masunaga, Shinichiro"}], "nameIdentifiers": [{"nameIdentifier": "464495", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sakurai, Yoshinori"}], "nameIdentifiers": [{"nameIdentifier": "464496", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka, Hiroki"}], "nameIdentifiers": [{"nameIdentifier": "464497", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirayama, Ryoichi"}], "nameIdentifiers": [{"nameIdentifier": "464498", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsumoto, Yoshitaka"}], "nameIdentifiers": [{"nameIdentifier": "464499", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Uzawa, Akiko"}], "nameIdentifiers": [{"nameIdentifier": "464500", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Minoru"}], "nameIdentifiers": [{"nameIdentifier": "464501", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kondo, Natsuko"}], "nameIdentifiers": [{"nameIdentifier": "464502", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Maruhashi, Akira"}], "nameIdentifiers": [{"nameIdentifier": "464503", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ono, Koji"}], "nameIdentifiers": [{"nameIdentifier": "464504", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "平山 亮一", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "464505", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "松本 孔貴", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "464506", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "鵜澤 玲子", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "464507", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "丸橋 晃", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "464508", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "小野 公二", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "464509", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Radiosensitivity of pimonidazole-unlabeled intratumor quiescent cell population to gamma-rays, accelerated carbon ion beams and boron neutron capture reaction", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Radiosensitivity of pimonidazole-unlabeled intratumor quiescent cell population to gamma-rays, accelerated carbon ion beams and boron neutron capture reaction"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/46598", "pubdate": {"attribute_name": "公開日", "attribute_value": "2013-09-27"}, "publish_date": "2013-09-27", "publish_status": "0", "recid": "46598", "relation": {}, "relation_version_is_last": true, "title": ["Radiosensitivity of pimonidazole-unlabeled intratumor quiescent cell population to gamma-rays, accelerated carbon ion beams and boron neutron capture reaction"], "weko_shared_id": -1}
Radiosensitivity of pimonidazole-unlabeled intratumor quiescent cell population to gamma-rays, accelerated carbon ion beams and boron neutron capture reaction
https://repo.qst.go.jp/records/46598
https://repo.qst.go.jp/records/46598360987cd-9a3a-4b2f-ac5a-4992a7225407
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2013-09-27 | |||||
タイトル | ||||||
タイトル | Radiosensitivity of pimonidazole-unlabeled intratumor quiescent cell population to gamma-rays, accelerated carbon ion beams and boron neutron capture reaction | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Masunaga, Shinichiro
× Masunaga, Shinichiro× Sakurai, Yoshinori× Tanaka, Hiroki× Hirayama, Ryoichi× Matsumoto, Yoshitaka× Uzawa, Akiko× Suzuki, Minoru× Kondo, Natsuko× Maruhashi, Akira× Ono, Koji× 平山 亮一× 松本 孔貴× 鵜澤 玲子× 丸橋 晃× 小野 公二 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objective: To detect the radiosensitivity of intratumour quiescent (Q) cells unlabelled with pimonidazole to accelerated carbon ion beams and the boron neutron capture reaction (BNCR). Methods: EL4 tumour-bearing C57BL/J mice received 5-bromo-29-deoxyuridine (BrdU) continuously to label all intratumour proliferating (P) cells. After the administration of pimonidazole, tumours were irradiated with c-rays, accelerated carbon ion beams or reactor neutron beams with the prior administration of a 10B-carrier. Responses of intratumour Q and total (P+Q) cell populations were assessed based on frequencies of micronucleation and apoptosis using immunofluorescence staining for BrdU. The response of pimonidazole-unlabelled tumour cells was assessed by means of apoptosis frequency using immunofluorescence staining for pimonidazole. Results: Following c-ray irradiation, the pimonidazole-unlabelled tumour cell fraction showed significantly enhanced radiosensitivity compared with the whole tumour cell fraction, more remarkably in the Q than total cell populations. However, a significantly greater decrease in radiosensitivity in the pimonidazole-unlabelled cell fraction, evaluated using a delayed assay or a decrease in radiation dose rate, was more clearly observed among the Q than total cells. These changes in radiosensitivity were suppressed following carbon ion beam and neutron beam-only irradiaton. In the BNCR, the use of a 10B-carrier, especially L-para-boronophenylalanine-10B, enhanced the sensitivity of the pimonidazole-unlabelled cells more clearly in the Q than total cells. Conclusion: The radiosensitivity of the pimonidazole-unlabelled cell fraction depends on the quality of radiation delivered and characteristics of the 10B-carrier used in the BNCR. |
|||||
書誌情報 |
British Journal of Radiology 巻 86, 号 1021, p. 20120302, 発行日 2013-03 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0007-1285 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1259/bjr.20120302 |