{"created":"2023-05-15T14:36:11.944499+00:00","id":46598,"links":{},"metadata":{"_buckets":{"deposit":"d0eca7ff-f9b9-4ce6-9158-1ec5b16aa19b"},"_deposit":{"created_by":1,"id":"46598","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46598"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046598","sets":["1"]},"author_link":["464502","464500","464499","464507","464495","464506","464497","464503","464504","464505","464508","464509","464498","464496","464501"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1021","bibliographicPageStart":"20120302","bibliographicVolumeNumber":"86","bibliographic_titles":[{"bibliographic_title":"British Journal of Radiology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: To detect the radiosensitivity of intratumour quiescent (Q) cells unlabelled with pimonidazole to accelerated carbon ion beams and the boron neutron capture reaction (BNCR).\nMethods: EL4 tumour-bearing C57BL/J mice received 5-bromo-29-deoxyuridine (BrdU)\ncontinuously to label all intratumour proliferating (P) cells. After the administration of pimonidazole, tumours were irradiated with c-rays, accelerated carbon ion beams or reactor neutron beams with the prior administration of a 10B-carrier. Responses of intratumour Q and total (P+Q) cell populations were assessed based on frequencies of micronucleation and apoptosis using immunofluorescence staining for BrdU. The response of pimonidazole-unlabelled tumour cells was assessed by means of apoptosis frequency using immunofluorescence staining for pimonidazole.\nResults: Following c-ray irradiation, the pimonidazole-unlabelled tumour cell fraction showed significantly enhanced radiosensitivity compared with the whole tumour cell fraction, more remarkably in the Q than total cell populations. However, a significantly greater decrease in radiosensitivity in the pimonidazole-unlabelled cell fraction, evaluated using a delayed assay or a decrease in radiation dose rate, was more clearly observed among the Q than total cells. These changes in radiosensitivity were suppressed following carbon ion beam and neutron beam-only irradiaton. In the BNCR, the use of a 10B-carrier, especially L-para-boronophenylalanine-10B, enhanced the sensitivity of the pimonidazole-unlabelled cells more clearly in the Q than total cells.\nConclusion: The radiosensitivity of the pimonidazole-unlabelled cell fraction depends on the quality of radiation delivered and characteristics of the 10B-carrier used in the BNCR.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1259/bjr.20120302","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0007-1285","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Masunaga, Shinichiro"}],"nameIdentifiers":[{"nameIdentifier":"464495","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakurai, Yoshinori"}],"nameIdentifiers":[{"nameIdentifier":"464496","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"464497","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirayama, Ryoichi"}],"nameIdentifiers":[{"nameIdentifier":"464498","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumoto, Yoshitaka"}],"nameIdentifiers":[{"nameIdentifier":"464499","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uzawa, Akiko"}],"nameIdentifiers":[{"nameIdentifier":"464500","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Minoru"}],"nameIdentifiers":[{"nameIdentifier":"464501","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kondo, Natsuko"}],"nameIdentifiers":[{"nameIdentifier":"464502","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maruhashi, Akira"}],"nameIdentifiers":[{"nameIdentifier":"464503","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ono, Koji"}],"nameIdentifiers":[{"nameIdentifier":"464504","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平山 亮一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"464505","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 孔貴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"464506","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鵜澤 玲子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"464507","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"丸橋 晃","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"464508","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小野 公二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"464509","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Radiosensitivity of pimonidazole-unlabeled intratumor quiescent cell population to gamma-rays, accelerated carbon ion beams and boron neutron capture reaction","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Radiosensitivity of pimonidazole-unlabeled intratumor quiescent cell population to gamma-rays, accelerated carbon ion beams and boron neutron capture reaction"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-09-27"},"publish_date":"2013-09-27","publish_status":"0","recid":"46598","relation_version_is_last":true,"title":["Radiosensitivity of pimonidazole-unlabeled intratumor quiescent cell population to gamma-rays, accelerated carbon ion beams and boron neutron capture reaction"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:49:51.803718+00:00"}