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C-ion RT alone was performed for 33 patients constituting a low-risk group (Stage \u003c or =T2a and PSA \u003c20 ng/ml and Gleason score \u003c or =6); the remaining 142 high-risk patients received an additional androgen deprivation therapy (ADT).\n\\nRESULTS: The 4-year overall survival and bNED rates were 91% and 87%, respectively. Local control was achieved in all but one patient. The 4-year bNED rates were 87% in the low-risk group and 88% in the high-risk group. In very advanced diseases (Stage \u003e or= T3a or PSA \u003e or= 20 ng/ml or Gleason score \u003e or =8), there was significant difference in the bNED rate according to period of ADT administration (ADT \u003e or =24 months: 93%, ADT \u003c24 months: 73%, p\u003c0.01). Grade 2 late toxicities developed in 4 patients (2%) for the rectum and 9 patients (5%) for the genitourinary system but no Grade 3 or higher toxicity was observed.\n\\nCONCLUSIONS: The effectiveness of C-ion RT for prostate cancer has been well confirmed. 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Carbon-ion radiation therapy for prostate cancer
https://repo.qst.go.jp/records/46376
https://repo.qst.go.jp/records/463764bdc8aea-c637-461d-90ac-39002a9315eb
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-08-09 | |||||
タイトル | ||||||
タイトル | Carbon-ion radiation therapy for prostate cancer | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Ishikawa, Hitoshi
× Ishikawa, Hitoshi× Tsuji, Hiroshi× Kamada, Tadashi× Akakura, Kouichirou× Suzuki, Hiroyosi× Shimazaki, Jun× Tsujii, Hirohiko× 石川 仁× 辻 比呂志× 鎌田 正× 赤倉 功一郎× 鈴木 啓悦× 島崎 淳× 辻井 博彦 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | BACKGROUND AND PURPOSE: To determine the efficacy and feasibility of carbon ion radiotherapy (C-ion RT) for prostate cancer. \nPATIENTS AND METHODS: Between April 2000 and November 2003, 175 patients received C-ion RT using a recommended dose fractionation (66.0 GyE/20 fractions) established from prior studies. C-ion RT alone was performed for 33 patients constituting a low-risk group (Stage < or =T2a and PSA <20 ng/ml and Gleason score < or =6); the remaining 142 high-risk patients received an additional androgen deprivation therapy (ADT). \nRESULTS: The 4-year overall survival and bNED rates were 91% and 87%, respectively. Local control was achieved in all but one patient. The 4-year bNED rates were 87% in the low-risk group and 88% in the high-risk group. In very advanced diseases (Stage > or= T3a or PSA > or= 20 ng/ml or Gleason score > or =8), there was significant difference in the bNED rate according to period of ADT administration (ADT > or =24 months: 93%, ADT <24 months: 73%, p<0.01). Grade 2 late toxicities developed in 4 patients (2%) for the rectum and 9 patients (5%) for the genitourinary system but no Grade 3 or higher toxicity was observed. \nCONCLUSIONS: The effectiveness of C-ion RT for prostate cancer has been well confirmed. Based on these results, new study of a C-ion RT modified for the administration strategy of ADT according to the patient risk has been started by dividing patients into 3 groups, high-risk, intermediate-risk, and low-risk. |
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書誌情報 |
International Journal of Urology 巻 19, 号 4, p. 296-305, 発行日 2012-04 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0919-8172 |