@article{oai:repo.qst.go.jp:00046376,
 author = {Ishikawa, Hitoshi and Tsuji, Hiroshi and Kamada, Tadashi and Akakura, Kouichirou and Suzuki, Hiroyosi and Shimazaki, Jun and Tsujii, Hirohiko and 石川 仁 and 辻 比呂志 and 鎌田 正 and 赤倉 功一郎 and 鈴木 啓悦 and 島崎 淳 and 辻井 博彦},
 issue = {4},
 journal = {International Journal of Urology},
 month = {Apr},
 note = {BACKGROUND AND PURPOSE: To determine the efficacy and feasibility of carbon ion radiotherapy (C-ion RT) for prostate cancer.
\nPATIENTS AND METHODS: Between April 2000 and November 2003, 175 patients received C-ion RT using a recommended dose fractionation (66.0 GyE/20 fractions) established from prior studies. C-ion RT alone was performed for 33 patients constituting a low-risk group (Stage < or =T2a and PSA <20 ng/ml and Gleason score < or =6); the remaining 142 high-risk patients received an additional androgen deprivation therapy (ADT).
\nRESULTS: The 4-year overall survival and bNED rates were 91% and 87%, respectively. Local control was achieved in all but one patient. The 4-year bNED rates were 87% in the low-risk group and 88% in the high-risk group. In very advanced diseases (Stage > or= T3a or PSA > or= 20 ng/ml or Gleason score > or =8), there was significant difference in the bNED rate according to period of ADT administration (ADT > or =24 months: 93%, ADT <24 months: 73%, p<0.01). Grade 2 late toxicities developed in 4 patients (2%) for the rectum and 9 patients (5%) for the genitourinary system but no Grade 3 or higher toxicity was observed.
\nCONCLUSIONS: The effectiveness of C-ion RT for prostate cancer has been well confirmed. Based on these results, new study of a C-ion RT modified for the administration strategy of ADT according to the patient risk has been started by dividing patients into 3 groups, high-risk, intermediate-risk, and low-risk.},
 pages = {296--305},
 title = {Carbon-ion radiation therapy for prostate cancer},
 volume = {19},
 year = {2012}
}