WEKO3
アイテム
[18F]FMDAA1106 and [18F]FEDAA1106: Two Positron-Emitter Labeled Ligands for Peripheral Benzodiazepine Receptor(PBR).
https://repo.qst.go.jp/records/44351
https://repo.qst.go.jp/records/443514ebf16b2-216d-4b19-bcca-ef6e7b6b92b2
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-06-26 | |||||
| タイトル | ||||||
| タイトル | [18F]FMDAA1106 and [18F]FEDAA1106: Two Positron-Emitter Labeled Ligands for Peripheral Benzodiazepine Receptor(PBR). | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Zhang, Ming-Rong
× Zhang, Ming-Rong× Maeda, Jun× Furutsuka, Kenji× Yoshida, Yuichirou× Ogawa, Masanao× Suhara, Tetsuya× Suzuki, Kazutoshi× 張 明栄× 前田 純× 古塚 賢士× 吉田 勇一郎× 小川 政直× 須原 哲也× 鈴木 和年 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We synthesized and evaluated N-(5-fluoro-2-phenoxyphenyl)-N-(2-[18F]fluoromethyl-5-methoxybenzyl)acetamide ([18F]-FMDAA1106) and N-(5-fluoro-2-phenoxyphenyl)-N-(2-[18F]fluoroethyl-5-methoxybenzyl)acetamide ([18F]FEDAA1106) as two potent radioligands for peripheral benzodiazepine receptors (PBR). [18F]FMDAA1106 and [18F]FEDAA1106 were respectively synthesized by fluoroalkylation of the desmethyl precursor DAA1123 with [18F]FCH2I and [18F]FCH2CH2Br. Ex vivo autoradiograms of [18F]FMDAA1106 and [18F]FEDAA1106 binding sites in the rat brains revealed that a high radioactivity was present in the olfactory bulb, the highest PBR density region in the brain. | |||||
| 書誌情報 |
Bioorganic & Medicinal Chemistry Letters 巻 13, p. 201-204, 発行日 2003 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0960-894X | |||||
