@article{oai:repo.qst.go.jp:00044351, author = {Zhang, Ming-Rong and Maeda, Jun and Furutsuka, Kenji and Yoshida, Yuichirou and Ogawa, Masanao and Suhara, Tetsuya and Suzuki, Kazutoshi and 張 明栄 and 前田 純 and 古塚 賢士 and 吉田 勇一郎 and 小川 政直 and 須原 哲也 and 鈴木 和年}, journal = {Bioorganic & Medicinal Chemistry Letters}, month = {}, note = {We synthesized and evaluated N-(5-fluoro-2-phenoxyphenyl)-N-(2-[18F]fluoromethyl-5-methoxybenzyl)acetamide ([18F]-FMDAA1106) and N-(5-fluoro-2-phenoxyphenyl)-N-(2-[18F]fluoroethyl-5-methoxybenzyl)acetamide ([18F]FEDAA1106) as two potent radioligands for peripheral benzodiazepine receptors (PBR). [18F]FMDAA1106 and [18F]FEDAA1106 were respectively synthesized by fluoroalkylation of the desmethyl precursor DAA1123 with [18F]FCH2I and [18F]FCH2CH2Br. Ex vivo autoradiograms of [18F]FMDAA1106 and [18F]FEDAA1106 binding sites in the rat brains revealed that a high radioactivity was present in the olfactory bulb, the highest PBR density region in the brain.}, pages = {201--204}, title = {[18F]FMDAA1106 and [18F]FEDAA1106: Two Positron-Emitter Labeled Ligands for Peripheral Benzodiazepine Receptor(PBR).}, volume = {13}, year = {2003} }