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Dose-Response and Large Relative Biological Effectiveness of Fast Neutrons with Regard to Mouse Fetal Cerebral Neuron Apoptosis
https://repo.qst.go.jp/records/44252
https://repo.qst.go.jp/records/4425231af39a6-a54d-4498-8b02-4ff84c287254
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-06-13 | |||||
| タイトル | ||||||
| タイトル | Dose-Response and Large Relative Biological Effectiveness of Fast Neutrons with Regard to Mouse Fetal Cerebral Neuron Apoptosis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ishida, Yuka
× Ishida, Yuka× Ohmachi, Yasushi× Nakata, Yukiko× Hiraoka, Takeshi× Hamano, Tsuyoshi× Fushiki, Shinji× Ogiu, Toshiaki× 石田 有香× 大町 康× 平岡 武× 濱野 毅× 伏木 信次× 荻生 俊昭 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To evaluate the relative biological effectiveness (RBE) of low doses of neutrons on fetal nervous development, [C57BL/6J * C3H/He] hybrid (B6C3F1) mice were exposed to cyclotron-derived fast neutrons with peak energy of 10 MeV (0.02-1.0 Gy) or 137Cs-generated gamma-rays (0.1-2.0 Gy) on embryonic day 13.5. We then evaluated the incidence of neuronal apoptosis in the cerebral cortex 24 hours after irradiation. Neuronal apoptosis increased in a dose-dependent manner in both neutron- and gamma-rays-irradiated groups: even at the lowest dose, a minimal increase in the apoptotic index was noted in response to both types of radiation. The dose-response curves were best fitted to linear quadratic models, and the evaluated RBE was 9.8, which was considered to be large for a prenatal effect and acute tissue injury induced by a low dose of neutrons. | |||||
| 書誌情報 |
Journal of Radiation Research 巻 47, 号 1, p. 41-47, 発行日 2006-04 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
