@article{oai:repo.qst.go.jp:00044252,
 author = {Ishida, Yuka and Ohmachi, Yasushi and Nakata, Yukiko and Hiraoka, Takeshi and Hamano, Tsuyoshi and Fushiki, Shinji and Ogiu, Toshiaki and 石田 有香 and 大町 康 and 平岡 武 and 濱野 毅 and 伏木 信次 and 荻生 俊昭},
 issue = {1},
 journal = {Journal of Radiation Research},
 month = {Apr},
 note = {To evaluate the relative biological effectiveness (RBE) of low doses of neutrons on fetal nervous development, [C57BL/6J * C3H/He] hybrid (B6C3F1) mice were exposed to cyclotron-derived fast neutrons with peak energy of 10 MeV (0.02-1.0 Gy) or 137Cs-generated gamma-rays (0.1-2.0 Gy) on embryonic day 13.5. We then evaluated the incidence of neuronal apoptosis in the cerebral cortex 24 hours after irradiation. Neuronal apoptosis increased in a dose-dependent manner in both neutron- and gamma-rays-irradiated groups: even at the lowest dose, a minimal increase in the apoptotic index was noted in response to both types of radiation. The dose-response curves were best fitted to linear quadratic models, and the evaluated RBE was 9.8, which was considered to be large for a prenatal effect and acute tissue injury induced by a low dose of neutrons.},
 pages = {41--47},
 title = {Dose-Response and Large Relative Biological Effectiveness of Fast Neutrons with Regard to Mouse Fetal Cerebral Neuron Apoptosis},
 volume = {47},
 year = {2006}
}